ARRB1 293T Cell Transient Overexpression Lysate(Denatured)
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More Files
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-ARRB1 full-length
Host
Human
Theoretical MW (kDa)
47.1
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-ARRB1 antibody (H00000408-D01P) by Western Blots.
SDS-PAGE Gel
ARRB1 transfected lysate.
Western Blot
Lane 1: ARRB1 transfected lysate ( 47.1 KDa)
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — ARRB1
Entrez GeneID
408GeneBank Accession#
NM_004041Protein Accession#
NP_004032.2Gene Name
ARRB1
Gene Alias
ARB1, ARR1
Gene Description
arrestin, beta 1
Omim ID
107940Gene Ontology
HyperlinkGene Summary
Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described, however, their exact functions are not known. [provided by RefSeq
Other Designations
arrestin 2|arrestin beta 1
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Interactome
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Pathway
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Disease
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