ARHGAP6 monoclonal antibody (M01), clone 6B3
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More Files
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Specification
Product Description
Mouse monoclonal antibody raised against a partial recombinant ARHGAP6.
Immunogen
ARHGAP6 (NP_038286, 531 a.a. ~ 636 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
RHADDNISKDGQEVTGNKMTSLNLATIFGPNLLHKQKSSDKEFSVQSSARAEESTAIIAVVQKMIENYEALFMVPPDLQNEVLISLLETDPDVVDYLLRRKASQSS
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (98)
Isotype
IgG2a Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (37.4 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Cell lysate)
ARHGAP6 monoclonal antibody (M01), clone 6B3 Western Blot analysis of ARHGAP6 expression in K-562 ( Cat # L009V1 ).Western Blot (Recombinant protein)
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged ARHGAP6 is approximately 0.3ng/ml as a capture antibody.ELISA
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Gene Info — ARHGAP6
Entrez GeneID
395GeneBank Accession#
NM_013427Protein Accession#
NP_038286Gene Name
ARHGAP6
Gene Alias
RHOGAP6, RHOGAPX-1
Gene Description
Rho GTPase activating protein 6
Omim ID
300118Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the rhoGAP family of proteins which play a role in the regulation of actin polymerization at the plasma membrane during several cellular processes. This protein is thought to have two independent functions, one as a GTPase-activating protein with specificity for RhoA, and another as a cytoskeletal protein that promotes actin remodeling. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000022913|OTTHUMP00000022915|OTTHUMP00000022916|OTTHUMP00000022918|Rho-type GTPase-activating protein RhoGAPX-1
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Interactome
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Disease
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Publication Reference
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Genetic screening in C. Elegans identifies rho- GTPase activating protein 6 as novel HERG regulator.
Potet F, Petersen CI, Boutaud O, Shuai W, Stepanovic SZ, Balser JR, Kupershmidt S.
Journal of Molecular and Cellular Cardiology 2008 Nov; 46(2):257.
Application:IF,WB, Mouse, Mouse atrial myocyte cell line HL-1 cells.
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Genetic screening in C. Elegans identifies rho- GTPase activating protein 6 as novel HERG regulator.
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