Products

Western Blot (Cell lysate)

Western Blot (Cell lysate)

Western Blot (Cell lysate)

ELISA

Entrez GeneID

GeneBank Accession#

Protein Accession#

Gene Name

AR

Gene Alias

AIS, DHTR, HUMARA, KD, NR3C4, SBMA, SMAX1, TFM

Gene Description

androgen receptor

Omim ID

Gene Ontology

Gene Summary

The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq

Other Designations

OTTHUMP00000023450|OTTHUMP00000061928|dihydrotestosterone receptor