AQP4 (Human) Recombinant Protein (P01)
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More Files
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Specification
Product Description
Human AQP4 full-length ORF (AAH22286.1, 1 a.a. - 323 a.a.) recombinant protein with GST tag at N-terminal.
Sequence
MSDRPTARRWGKCGPLCTRENIMVAFKGVWTQAFWKAVTAEFLAMLIFVLLSLGSTINWGGTEKPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFYIAAQCLGAIIGAGILYLVTPPSVVGGLGVTMVHGNLTAGHGLLVELIITFQLVFTIFASCDSKRTDVTGSIALAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIGAVLAGGLYEYVFCPDVEFKRRFKEAFSKAAQQTKGSYMEVEDNRSQVETDDLILKPGVVHVIDVDRGEEKKGKDQSGEVLSSV
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
61.2
Interspecies Antigen Sequence
Mouse (93); Rat (94)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — AQP4
Entrez GeneID
361GeneBank Accession#
BC022286.1Protein Accession#
AAH22286.1Gene Name
AQP4
Gene Alias
HMIWC2, MGC22454, MIWC
Gene Description
aquaporin 4
Omim ID
600308Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the aquaporin family of intrinsic membrane proteins that function as water-selective channels in the plasma membranes of many cells. The encoded protein is the predominant aquaporin found in brain. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq
Other Designations
aquaporin type4|aquaporin-4|mercurial-insensitive water channel
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Interactome
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Disease
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Publication Reference
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Anti-aquaporin-4 immune complex stimulates complement-dependent Th17 cytokine release in neuromyelitis optica spectrum disorders.
Shuhei Nishiyama, Jin Myong Seok, Amy E Wright, Itay Lotan, Takahisa Mikami, Natalia C Drosu, Natasha Bobrowski-Khoury, Monique R Anderson, Philippe A Bilodeau, Patrick Schindler, Friedemann Paul, Masashi Aoki, Michael R Yeaman, Michael Levy.
Scientific Reports 2024 Feb; 14(1):3146.
Application:Flow Cyt, Human serum, Peripheral blood mononuclear cells.
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Anti-aquaporin-4 immune complex stimulates complement-dependent Th17 cytokine release in neuromyelitis optica spectrum disorders.
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