Proximity Ligation Analysis of protein-protein interactions between BIRC2 and CASP9. HeLa cells were stained with anti-BIRC2 rabbit purified polyclonal 1:1200 and anti-CASP9 mouse monoclonal antibody 1:50. Each red dot represents the detection of protein-protein interaction complex, and nuclei were counterstained with DAPI (blue).
The protein encoded by this gene is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. This encoded protein inhibits apoptosis induced by serum deprivation and menadione, a potent inducer of free radicals. [provided by RefSeq
NFR2-TRAF signalling complex protein,apoptosis inhibitor 1,baculoviral IAP repeat-containing protein 2