APC (Human) Recombinant Protein (Q01)
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More Files
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Specification
Product Description
Human APC partial ORF ( NP_000029, 2744 a.a. - 2843 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
NPVPVSETNESSIVERTPFSSSSSSKHSSPSGTVAARVTPFNYNPSPRKSSADSTSARPSQIPTPVNNNTKKRDSKTDSTESSGTQSPKRHSGSYLVTSV
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
36.85
Interspecies Antigen Sequence
Mouse (90); Rat (89)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — APC
Entrez GeneID
324GeneBank Accession#
NM_000038Protein Accession#
NP_000029Gene Name
APC
Gene Alias
BTPS2, DP2, DP2.5, DP3, GS
Gene Description
adenomatous polyposis coli
Gene Ontology
HyperlinkGene Summary
This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. [provided by RefSeq
Other Designations
adenomatosis polyposis coli tumor suppressor
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Interactome
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Pathway
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Disease
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Publication Reference
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Comparison of commercial nanoliquid chromatography columns for fast, targeted mass spectrometry-based proteomics.
Vehus T, Seterdal KE, Krauss S, Lundanes E, Wilson SR.
Future Science OA 2016 Mar; 2(2):FSO119.
Application:MS/MS, Recombinant protein.
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Comparison of commercial nanoliquid chromatography columns for fast, targeted mass spectrometry-based proteomics.
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