Western blot analysis of ANXA2 over-expressed 293 cell line, cotransfected with ANXA2 Validated Chimera RNAi ( Cat # H00000302-R01V ) (Lane 2) or non-transfected control (Lane 1). Blot probed with ANXA2 monoclonal antibody (M01), clone 3E8-B6 (Cat # H00000302-M01 ). GAPDH ( 36.1 kDa ) used as specificity and loading control.
This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions as an autocrine factor which heightens osteoclast formation and bone resorption. This gene has three pseudogenes located on chromosomes 4, 9 and 10, respectively. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
OTTHUMP00000163650,annexin II,calpactin I heavy polypeptide,chromobindin 8,lipocortin II,placental anticoagulant protein IV