ALOX5 293T Cell Transient Overexpression Lysate(Denatured)
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More Files
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-ALOX5 full-length
Host
Human
Theoretical MW (kDa)
78
Interspecies Antigen Sequence
Mouse (93)
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-ALOX5 antibody (H00000240-B01) by Western Blots.
SDS-PAGE Gel
ALOX5 transfected lysate.
Western Blot
Lane 1: ALOX5 transfected lysate ( 78 KDa)
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — ALOX5
Entrez GeneID
240GeneBank Accession#
NM_000698.2Protein Accession#
-Gene Name
ALOX5
Gene Alias
5-LO, 5-LOX, 5LPG, LOG5, MGC163204
Gene Description
arachidonate 5-lipoxygenase
Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants have been observed, but their full-length nature has not been determined. [provided by RefSeq
Other Designations
OTTHUMP00000019502|arachidonic acid 5-lipoxygenase|leukotriene A4 synthase
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Interactome
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Pathway
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Disease
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