AHCY monoclonal antibody (M07A), clone 4H2
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More Files
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Western Blot (Cell lysate)
AHCY monoclonal antibody (M07A), clone 4H2 Western Blot analysis of AHCY expression in A-549 ( Cat # L025V1 ).
Western Blot detection against Immunogen (73.26 KDa) .
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Specification
Product Description
Mouse monoclonal antibody raised against a full length recombinant AHCY.
Immunogen
AHCY (AAH11606, 1 a.a. ~ 432 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
MSDKLPYKVADIGLAAWGRKALDIAENEMPGLMRMRERYSASKPLKGARIAGCLHMTVETAVLIETLVTLGAEVQWSSCNIFSTQDHAAAAIAKAGIPVYAWKGETDEEYLWCIEQTLYFKDGPLNMILDDGGDLTNLIHTKHPQLLPGIRGISEETTTGVHNLYKMMANGILKVPAINVNDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITEIDPINALQAAMEGYEVTTMDEACQEGNIFVTTTGCIDIILGRHFEQMKDDAIVCNIGHFDVEIDVKWLNENAVEKVNIKPQVDRYRLKNGRRIILLAEGRLVNLGCAMGHPSFVMSNSFTNQVMAQIELWTHPDKYPVGVHFLPKKLDEAVAEAHLGKLNVKLTKLTEKQAQYLGMSCDGPFKPDHYRY
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (97); Rat (97)
Isotype
IgM Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (73.26 KDa) .
Storage Buffer
In ascites fluid
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Cell lysate)
AHCY monoclonal antibody (M07A), clone 4H2 Western Blot analysis of AHCY expression in A-549 ( Cat # L025V1 ).Western Blot (Recombinant protein)
ELISA
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Gene Info — AHCY
Entrez GeneID
191GeneBank Accession#
BC011606Protein Accession#
AAH11606Gene Name
AHCY
Gene Alias
SAHH
Gene Description
S-adenosylhomocysteine hydrolase
Omim ID
180960Gene Ontology
HyperlinkGene Summary
S-adenosylhomocysteine hydrolase belongs to the adenosylhomocysteinase family. It catalyzes the reversible hydrolysis of S-adenosylhomocysteine (AdoHcy) to adenosine (Ado) and L-homocysteine (Hcy). Thus, it regulates the intracellular S-adenosylhomocysteine (SAH) concentration thought to be important for transmethylation reactions. Deficiency in this protein is one of the different causes of hypermethioninemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000030684|adenosylhomocysteinase
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Interactome
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Pathway
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Disease
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Publication Reference
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S-adenosylhomocysteine hydrolase over-expression does not alter S-adenosylmethionine or S-adenosylhomocysteine levels in CBS deficient mice.
Lee HO, Wang L, Kuo YM, Andrews AJ, Gupta S, Kruger WD.
Molecular Genetics and Metabolism Reports 2018 Jan; 15:15.
Application：WB, Mouse, Mouse livers.
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Identification and pharmacological inactivation of the MYCN gene network as a therapeutic strategy for neuroblastic tumour cells.
Chayka O, D'Acunto CW, Middleton O, Arab M, Sala A.
The Journal of Biological Chemistry 2015 Jan; 290(4):2198.
Application：WB-Ce, Human, SK-N-AS, SH-SY5Y, IMR-32, SK-N-BE(2), LA-N-1, NB19, GI-M-EN, SMS-KCNR cells.
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S-Adenosyl Homocysteine Hydrolase (SAHH) is required for Myc-induced mRNA cap methylation, protein synthesis and cell proliferation.
Fernandez-Sanchez ME, Gonatopoulos-Pournatzis T, Preston G, Lawlor MA, Cowling VH.
Molecular and Cellular Biology 2009 Dec; 29(23):6182.
Application：WB-Ce, WB-Tr, Human, Mouse, Rat, IMEC, MEFs, P493-6, Rat1A, T cells.
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S-adenosylhomocysteine hydrolase over-expression does not alter S-adenosylmethionine or S-adenosylhomocysteine levels in CBS deficient mice.
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