ACACA (Human) Recombinant Protein (Q01)
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More Files
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Specification
Product Description
Human ACACA partial ORF ( NP_942131, 1 a.a. - 99 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MWWSTLMSILRARSFWKWISTQTVRIIRAVRAHFGGIMDEPSPLAQPLELNQHSRFIIGSVSEDNSEDEISNLVKLDLLEEKEGSLSPASVGSDTLSDL
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
36.63
Interspecies Antigen Sequence
Mouse (94); Rat (94)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — ACACA
Entrez GeneID
31GeneBank Accession#
NM_198834Protein Accession#
NP_942131Gene Name
ACACA
Gene Alias
ACAC, ACC, ACC1, ACCA
Gene Description
acetyl-Coenzyme A carboxylase alpha
Omim ID
200350Gene Ontology
HyperlinkGene Summary
Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene. [provided by RefSeq
Other Designations
ACC-alpha|OTTHUMP00000164069|acetyl-CoA carboxylase 1|acetyl-CoA carboxylase-alpha
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Interactome
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Pathway
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Disease
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