ABAT purified MaxPab mouse polyclonal antibody (B01P)
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More Files
- More Functions
Western Blot (Tissue lysate)
ABAT MaxPab polyclonal antibody. Western Blot analysis of ABAT expression in human liver.
Western Blot (Transfected lysate)
Western Blot analysis of ABAT expression in transfected 293T cell line (H00000018-T01) by ABAT MaxPab polyclonal antibody.
Lane 1: ABAT transfected lysate(55 KDa).
Lane 2: Non-transfected lysate.
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Specification
Product Description
Mouse polyclonal antibody raised against a full-length human ABAT protein.
Immunogen
ABAT (NP_000654.2, 1 a.a. ~ 500 a.a) full-length human protein.
Sequence
MASMLLAQRLACSFQHSYRLLVPGSRHISQAAAKVDVEFDYDGPLMKTEVPGPRSQELMKQLNIIQNAEAVHFFCNYEESRGNYLVDVDGNRMLDLYSQISSVPIGYSHPALLKLIQQPQNASMFVNRPALGILPPENFVEKLRQSLLSVAPKGMSQLITMACGSCSNENALKTIFMWYRSKERGQRGFSQEELETCMINQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRLKYPLEEFVKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKLRDIARKHGCAFLVDEVQTGGGCTGKFWAHEHWGLDDPADVMTFSKKMMTGGFFHKEEFRPNAPYRIFNTWLGDPSKNLLLAEVINIIKREDLLNNAAHAGKALLTGLLDLQARYPQFISRVRGRGTFCSFDTPDDSIRNKLILIARNKGVVLGGCGDKSIRFRPTLVFRDHHAHLFLNIFSDILADFK
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (91); Rat (92)
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Tissue lysate)
ABAT MaxPab polyclonal antibody. Western Blot analysis of ABAT expression in human liver.Western Blot (Transfected lysate)
Western Blot analysis of ABAT expression in transfected 293T cell line (H00000018-T01) by ABAT MaxPab polyclonal antibody.
Lane 1: ABAT transfected lysate(55 KDa).
Lane 2: Non-transfected lysate.
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Gene Info — ABAT
Entrez GeneID
18GeneBank Accession#
NM_000663.3Protein Accession#
NP_000654.2Gene Name
ABAT
Gene Alias
FLJ17813, GABA-AT, GABAT, NPD009
Gene Description
4-aminobutyrate aminotransferase
Omim ID
137150Gene Ontology
HyperlinkGene Summary
4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. The protein sequence is over 95% similar to the pig protein. GABA is estimated to be present in nearly one-third of human synapses. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. [provided by RefSeq
Other Designations
GABA aminotransferase|GABA transferase|gamma-amino-N-butyrate transaminase
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Interactome
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Pathway
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Disease
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Publication Reference
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Liver protein profiling in chronic hepatitis C: Identification of potential predictive markers for interferon therapy outcome.
Perdomo AB, Ciccosanti F, Iacono OL, Angeletti C, Corazzari M, Daniele N, Testa A, Pisa R, Ippolito G, Antonucci G, Fimia GM, Piacentini M.
Journal of Proteome Research 2012 Feb; 11(2):717.
Application：WB, Human, Liver.
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Liver protein profiling in chronic hepatitis C: Identification of potential predictive markers for interferon therapy outcome.
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