MYB/NFIB DY Translocation FISH Probe
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Specification
Product Description
Labeled FISH probes for identification of gene translocation using Fluorescent In Situ Hybridization Technique. (Technology).
Probe 1
Name: MYB
Size: Approximately 1010kb
Fluorophore: Texas Red
Location: 6q22-23Probe 2
Name: NFIB
Size: Approximately 1090kb
Fluorophore: FITC
Location: 9p24.1Origin
Human
Source
Genomic DNA
Reactivity
Human
Form
Liquid
Notice
We strongly recommend the customer to use FFPE FISH PreTreatment Kit 1 (Catalog #: KA2375 or KA2691) for the pretreatment of Formalin-Fixed Paraffin-Embedded (FFPE) tissue sections.
Regulation Status
For research use only (RUO)
Quality Control Testing
Representative images of normal human cell (lymphocyte) stain with the dual color FISH probe. The left image is chromosomes at metaphase, and the right image is an interphase nucleus.
Supplied Product
DAPI Counterstain (1500 ng/mL ) 125 uL for each 100 uL FISH Probe
Probe Position
Storage Instruction
Store at 4°C in the dark.
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Applications
Fluorescent In Situ Hybridization (Cell)
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Gene Info — MYB
Entrez GeneID
4602Gene Name
MYB
Gene Alias
Cmyb, c-myb, c-myb_CDS, efg
Gene Description
v-myb myeloblastosis viral oncogene homolog (avian)
Omim ID
189990Gene Ontology
HyperlinkGene Summary
This gene encodes a transcription factor that is a member of the MYB family of transcription factor genes. The protein contains three domains, an N-terminal DNA-binding domain, a central transcriptional activation domain and a C-terminal domain involved in transcriptional repression. This protein plays an essential role in the regulation of hematopoiesis and may play a role in tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq
Other Designations
Avian myeloblastosis viral (v-myb) oncogene homolog|OTTHUMP00000017258|c-myb protein (140 AA)|c-myb10A_CDS|c-myb13A_CDS|c-myb14A_CDS|c-myb8B_CDS|v-myb avian myeloblastosis viral oncogene homolog|v-myb myeloblastosis viral oncogene homolog
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Gene Info — NFIB
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Interactome
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Disease
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Publication Reference
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Serial patient-derived orthotopic xenografting of adenoid cystic carcinomas recapitulates stable expression of phenotypic alterations and innervation.
Cornett A, Athwal HK, Hill E, Murphy G 3rd, Yeoh K, Moskaluk CA, Witt RL, D'Silva NJ, Agarwal S, Lombaert IMA.
EBioMedicine 2019 Mar; 41:175.
Application：FISH, Human, Mouse, Adenoid cystic carcinoma.
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Serial patient-derived orthotopic xenografting of adenoid cystic carcinomas recapitulates stable expression of phenotypic alterations and innervation.
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