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ETV6/NTRK3 DY Translocation FISH Probe

  • Catalog # : FT0012
  • Visit Frequency :
  • Countries :
  • Specification
  • Product Description:
  • Labeled FISH probes for identification of gene translocation using Fluoresecent In Situ Hybridization Technique. (Technology)
  • Form:
  • Liquid
  • Quality Control Testing:
  • Representative images of normal human cell (lymphocyte) stain with the dual color FISH probe. The left image is chromosomes at metaphase, and the right image is an interphase nucleus.

    QC Testing of FT0012
  • Supplied Product:
  • DAPI Counterstain (1500 ng/mL ) 250 uL
  • Storage Instruction:
  • Store at 4°C in the dark.
  • Note:
  • Hybridization position of the probes on the chromosome.

  • Probe 1:
  • ETV6
    Approximately 910kb
    Texas Red
  • Probe 2:
  • NTRK3
    Approximately 1,200kb
  • Origin:
  • Human
  • Source:
  • Genomic DNA
  • Notice:
  • We strongly recommend the customer to use FFPE FISH PreTreatment Kit 1 (Catalog #: KA2375 or KA2691) for the pretreatment of Formalin-Fixed Paraffin-Embedded (FFPE) tissue sections.
  • Regulation Status:
  • For research use only (RUO)
  • Applications
  • Application Image
  • Fluorescent In Situ Hybridization (Cell)
  • Gene Information
  • Entrez GeneID:
  • 2120
  • Gene Name:
  • ETV6
  • Gene Alias:
  • Gene Description:
  • ets variant 6
  • Gene Summary:
  • This gene encodes an ETS family transcription factor. The product of this gene contains two functional domains: a N-terminal pointed (PNT) domain that is involved in protein-protein interactions with itself and other proteins, and a C-terminal DNA-binding domain. Gene knockout studies in mice suggest that it is required for hematopoiesis and maintenance of the developing vascular network. This gene is known to be involved in a large number of chromosomal rearrangements associated with leukemia and congenital fibrosarcoma. [provided by RefSeq
  • Other Designations:
  • TEL oncogene,TEL1 oncogene,ets variant gene 6 (TEL oncogene)
  • Gene Information
  • Entrez GeneID:
  • 4916
  • Gene Name:
  • NTRK3
  • Gene Alias:
  • TRKC,gp145(trkC)
  • Gene Description:
  • neurotrophic tyrosine kinase, receptor, type 3
  • Gene Summary:
  • This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. [provided by RefSeq
  • Other Designations:
  • ETS related protein-neurotrophic receptor tyrosine kinase fusion protein,ETV6-NTRK3 fusion,NT-3 growth factor receptor,OTTHUMP00000192915,neurotrophin 3 receptor,tyrosine kinase receptor C
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