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EML4/ALK Translocation FISH ProbeGMP

  • Catalog # : FT0009
  • Visit Frequency :
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  • Specification
  • Product Description:
  • Labeled FISH probes for identification of gene translocation using Fluorescent In Situ Hybridization Technique.
  • Quality Control Testing:
  • Representative images of human lung cancer cell stain with the dual color FISH probe. The left image is chromosomes at a normal cell hybridized with the ALK (Orange)/EML4 (Green). The cell in this image shows 2 orange signals (ALK) and 2 green signals (EML4); and the right image is at an abnormal cell shows the one orange, one green and one orange/green fusion signal, which indicates the EML4-ALK inversion/translocation.

    QC Testing of FT0009
  • Storage Instruction:
  • Store at -20°C in the dark.
  • Note:
  • Hybridization position of the probes on the chromosome.

  • Probe 1:
        Size:
        Fluorophore:
        Location:
  • ALK
    Approximately 193kb
    Orange
    2p23.2
  • Probe 2:
        Size:
        Fluorophore:
        Location:
  • EML4
    Approximately 185kb
    Green
    2p21
  • Origin:
  • Human
  • Source:
  • Genomic DNA
  • Regulation Status:
  • For research use only (RUO)
  • Applications
  • Application Image
  • Fluorescent In Situ Hybridization
  • Gene Information
  • Gene Name:
  • EML4
  • Gene Alias:
  • C2orf2,DKFZp686P18118,ELP120,FLJ10942,FLJ32318,ROPP120
  • Gene Description:
  • echinoderm microtubule associated protein like 4
  • Other Designations:
  • -
  • Gene Information
  • Entrez GeneID:
  • 238
  • Gene Name:
  • ALK
  • Gene Alias:
  • CD246,Ki-1,TFG/ALK
  • Gene Description:
  • anaplastic lymphoma receptor tyrosine kinase
  • Gene Summary:
  • The 2;5 chromosomal translocation is frequently associated with anaplastic large cell lymphomas (ALCLs). The translocation creates a fusion gene consisting of the ALK (anaplastic lymphoma kinase) gene and the nucleophosmin (NPM) gene: the 3' half of ALK, derived from chromosome 2, is fused to the 5' portion of NPM from chromosome 5. A recent study shows that the product of the NPM-ALK fusion gene is oncogenic. The deduced amino acid sequences reveal that ALK is a novel receptor protein-tyrosine kinase having a putative transmembrane domain and an extracellular domain. These sequences are absent in the product of the transforming NPM-ALK gene. ALK shows the greatest sequence similarity to LTK (leukocyte tyrosine kinase). ALK plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. [provided by RefSeq
  • Other Designations:
  • ALK tyrosine kinase receptor,CD246 antigen,anaplastic lymphoma kinase (Ki-1),anaplastic lymphoma kinase Ki-1
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