NTRK1 Split FISH Probe
* The price is valid only in USA. Please select country.
-
More Files
- More Functions
Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
Human hepatocellular carcinoma (FFPE) stained with TRKA Split FISH Probe. Human hepatocellular carcinoma showed no TRKA gene split.
Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
Human colon cancer (FFPE) stained with TRKA Split FISH Probe. Human colon cancer showed no TRKA gene split.
Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
Human ovary cancer (FFPE) stained with TRKA Split FISH Probe. Human ovary cancer showed TRKA gene split.
Hybridization position of the probes on the chromosome:
Hybridization position of the probes on the chromosome:
-
Specification
Product Description
Labeled FISH probes for identification of gene split using Fluorescent In Situ Hybridization Technique. (Technology).
Probe 1
Name: NTRK1
Size: Approximately 420kb
Fluorophore: TexRed
Location: 1q23.1Probe 2
Name: NTRK1
Size: Approximately 780kb
Fluorophore: FITC
Location: 1q23.1Probe Gap
The gap between two probes is approximately 40 kb.
Origin
Human
Source
Genomic DNA
Reactivity
Human
Form
Liquid
Notice
We strongly recommend the customer to use FFPE FISH PreTreatment Kit 1 (Catalog #: KA2375 or KA2691) for the pretreatment of Formalin-Fixed Paraffin-Embedded (FFPE) tissue sections.
Regulation Status
For research use only (RUO)
Quality Control Testing
Representative images of normal human cell (lymphocyte) stain with the dual color FISH probe. The left image is chromosomes at metaphase, and the right image is an interphase nucleus.
Supplied Product
DAPI Counterstain (1500 ng/mL ) 125 uL for each 100 uL FISH Probe
Storage Instruction
Store at 4°C in the dark.
Note
Hybridization position of the probes on the chromosome:
-
Applications
Fluorescent In Situ Hybridization (Cell)
Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
Human hepatocellular carcinoma (FFPE) stained with TRKA Split FISH Probe. Human hepatocellular carcinoma showed no TRKA gene split.Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
Human colon cancer (FFPE) stained with TRKA Split FISH Probe. Human colon cancer showed no TRKA gene split.Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
Human ovary cancer (FFPE) stained with TRKA Split FISH Probe. Human ovary cancer showed TRKA gene split. -
Gene Info — NTRK1
Entrez GeneID
4914Gene Name
NTRK1
Gene Alias
DKFZp781I14186, MTC, TRK, TRK1, TRKA, p140-TrkA
Gene Description
neurotrophic tyrosine kinase, receptor, type 1
Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date. [provided by RefSeq
Other Designations
OTTHUMP00000038736|Oncogene TRK|high affinity nerve growth factor receptor|tyrosine kinase receptor A
-
Interactome
-
Pathway
-
Disease
-
Publication Reference
-
Cytoplasmic TrkA Expression as a Screen for Detecting NTRK1 Fusions in Colorectal Cancer.
Choi Y, Won YJ, Lee S, Kim A, Kim Y, Park WY, Jo HJ, Song GA, Kwon CH, Park DY.
Translational Oncology 2018 Jun; 11(3):764.
Application：FISH-P, Human, Colorectal cancer tissues.
-
NTRK1 fusions for the therapeutic intervention of Korean patients with colon cancer.
Do Youn Park, Chan Choi, Eunji Shin, Jae Hyuk Lee, Chae Hwa Kwon1, Hong-Jae Jo, Hyeong-Rok Kim, Hyun Sung Kim, Nahmgun Oh, Ji Shin Lee, Ok Ku Park, Eok Park, Jonghoon Park, Jong-Yeon Shin, Jong-Il Kim, Jeong-Sun Seo, Hee Dong Park and Joonghoon Park.
Oncotarget 2016 Feb; 7(7):8399.
Application：FISH-P, Human, Human colon adenocarcinoma.
-
Cytoplasmic TrkA Expression as a Screen for Detecting NTRK1 Fusions in Colorectal Cancer.
- +1-909-264-1399
+1-909-992-0619
Toll Free : +1-877-853-6098 - +1-909-992-3401
- sales@abnova.com