NR4A3 Split FISH Probe
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Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
Human colon adenocarcinoma (FFPE) stained with NR4A3 Split FISH Probe. Human colon adenocarcinoma showed no NR4A3 gene split.
Hybridization position of the probes on the chromosome:
Hybridization position of the probes on the chromosome:
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Specification
Product Description
Labeled FISH probes for identification of gene split using Fluorescent In Situ Hybridization Technique. (Technology).
Probe 1
Name: NR4A3(Texas Red)
Size: Approximately 450kb
Fluorophore: Texas Red
Location: 9q31.1Probe 2
Name: NR4A3(FITC)
Size: Approximately 720kb
Fluorophore: FITC
Location: 9q22.3Probe Gap
The gap between two probes is approximately 35 kb.
Origin
Human
Source
Genomic DNA
Reactivity
Human
Form
Liquid
Notice
We strongly recommend the customer to use FFPE FISH PreTreatment Kit 1 (Catalog #: KA2375 or KA2691) for the pretreatment of Formalin-Fixed Paraffin-Embedded (FFPE) tissue sections.
Regulation Status
For research use only (RUO)
Quality Control Testing
Representative images of normal human cell (lymphocyte) stain with the dual color FISH probe. The left image is chromosomes at metaphase, and the right image is an interphase nucleus.
Supplied Product
DAPI Counterstain (1500 ng/mL ) 125 uL for each 100 uL FISH Probe
Storage Instruction
Store at 4°C in the dark.
Note
Hybridization position of the probes on the chromosome:
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Applications
Fluorescent In Situ Hybridization (Cell)
Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
Human colon adenocarcinoma (FFPE) stained with NR4A3 Split FISH Probe. Human colon adenocarcinoma showed no NR4A3 gene split. -
Gene Info — NR4A3
Entrez GeneID
8013Gene Name
NR4A3
Gene Alias
CHN, CSMF, MINOR, NOR1, TEC
Gene Description
nuclear receptor subfamily 4, group A, member 3
Omim ID
600542Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcriptional activator. The protein can efficiently bind the NGFI-B Response Element (NBRE). Three different versions of extraskeletal myxoid chondrosarcomas (EMCs) are the result of reciprocal translocations between this gene and other genes. The translocation breakpoints are associated with Nuclear Receptor Subfamily 4, Group A, Member 3 (on chromosome 9) and either Ewing Sarcome Breakpoint Region 1 (on chromosome 22), RNA Polymerase II, TATA Box-Binding Protein-Associated Factor, 68-KD (on chromosome 17), or Transcription factor 12 (on chromosome 15). Four transcript variants encoding three distinct isoforms have been identified for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000022775|OTTHUMP00000022776|chondrosarcoma, extraskeletal myxoid, fused to EWS|mitogen induced nuclear orphan receptor|neuron derived orphan receptor|translocated in extraskeletal chondrosarcoma
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Interactome
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Disease
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Publication Reference
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Establishment, characterization and functional testing of two novel ex vivo extraskeletal myxoid chondrosarcoma (EMC) cell models.
Jana Lucia Bangerter, Kim Jannis Harnisch, Yanjiang Chen, Catherine Hagedorn, Lara Planas-Paz, Chantal Pauli.
Human Cell 2023 Jan; 36(1):446.
Application：FISH-Ce, Human, USZ20-EMC1, USZ22-EMC2 cells.
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Establishment, characterization and functional testing of two novel ex vivo extraskeletal myxoid chondrosarcoma (EMC) cell models.
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