RET Split FISH Probe (V.2)
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More Files
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Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
Human lung, adenosquamous cell carcinoma (FFPE) stained with RET Split FISH Probe. Huma lung, adenosquamous cell carcinoma showed no RET gene split.
Hybridization position of the probes on the chromosome:
Hybridization position of the probes on the chromosome:
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Specification
Product Description
Labeled FISH probes for identification of gene split using Fluorescent In Situ Hybridization Technique. (Technology).
Probe 1
Name: RET(Texas Red)
Size: Approximately 490kb
Fluorophore: Texas Red
Location: 10q11.2Probe 2
Name: RET(FITC)
Size: Approximately 630kb
Fluorophore: FITC
Location: 10q11.2Origin
Human
Source
Genomic DNA
Reactivity
Human
Notice
We strongly recommend the customer to use FFPE FISH PreTreatment Kit 1 (Catalog #: KA2375 or KA2691) for the pretreatment of Formalin-Fixed Paraffin-Embedded (FFPE) tissue sections.
Regulation Status
For research use only (RUO)
Quality Control Testing
Representative images of normal human cell (lymphocyte) stain with the dual color FISH probe. The left image is chromosomes at metaphase, and the right image is an interphase nucleus.
Supplied Product
DAPI Counterstain (1500 ng/mL ) 250 uL
Storage Instruction
Store at 4°C in the dark.
Note
Hybridization position of the probes on the chromosome:
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Applications
Fluorescent In Situ Hybridization (Cell)
Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
Human lung, adenosquamous cell carcinoma (FFPE) stained with RET Split FISH Probe. Huma lung, adenosquamous cell carcinoma showed no RET gene split. -
Gene Info — RET
Entrez GeneID
5979Gene Name
RET
Gene Alias
CDHF12, HSCR1, MEN2A, MEN2B, MTC1, PTC, RET-ELE1, RET51
Gene Description
ret proto-oncogene
Gene Ontology
HyperlinkGene Summary
This gene, a member of the cadherin superfamily, encodes one of the receptor tyrosine kinases, which are cell-surface molecules that transduce signals for cell growth and differentiation. This gene plays a crucial role in neural crest development, and it can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Mutations in this gene are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma. Two transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their biological validity has not been confirmed. [provided by RefSeq
Other Designations
RET transforming sequence|cadherin family member 12|hydroxyaryl-protein kinase|oncogene RET|receptor tyrosine kinase|ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease)
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Interactome
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Pathway
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Disease
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Publication Reference
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RET expression and detection of KIF5B/RET gene rearrangements in Japanese lung cancer.
Sasaki H, Shimizu S, Tani Y, Maekawa M, Okuda K, Yokota K, Shitara M, Hikosaka Y, Moriyama S, Yano M, Fujii Y.
Cancer Medicine 2012 Aug; 1(1):68.
Application：Func, Human, Human lung cancer.
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RET expression and detection of KIF5B/RET gene rearrangements in Japanese lung cancer.
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