EWSR1 Split FISH Probe
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Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
Human Ewing's sarcoma (FFPE) stained with EWSR1 Split FISH Probe. Human Ewing's sarcoma showed EWSR1 gene split.
Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
Human myoepithelioma (FFPE) stained with EWSR1 Split FISH Probe. Human myoepithelioma showed EWSR1 gene split.
Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
Human breast cancer (FFPE) stained with EWSR1 Split FISH Probe. Human breast cancer showed EWSR1 gene split.
Hybridization position of the probes on the chromosome.
Hybridization position of the probes on the chromosome.
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Specification
Product Description
Labeled FISH probes for identification of gene split using Fluorescent In Situ Hybridization Technique. (Technology).
Probe 1
Name: EWSR1(Texas Red)
Size: Approximately 590kb
Fluorophore: Texas Red
Location: 22q12Probe 2
Name: EWSR1(FITC)
Size: Approximately 610kb
Fluorophore: FITC
Location: 22q12Probe Gap
The gap between two probes is approximately 40 kb.
Origin
Human
Source
Genomic DNA
Reactivity
Human
Form
Liquid
Notice
We strongly recommend the customer to use FFPE FISH PreTreatment Kit 1 (Catalog #: KA2375 or KA2691) for the pretreatment of Formalin-Fixed Paraffin-Embedded (FFPE) tissue sections.
Regulation Status
For research use only (RUO)
Quality Control Testing
Representative images of normal human cell (lymphocyte) stain with the dual color FISH probe. The left image is chromosomes at metaphase, and the right image is an interphase nucleus.
Supplied Product
DAPI Counterstain (1500 ng/mL ) 125 uL for each 100 uL FISH Probe
Storage Instruction
Store at 4°C in the dark.
Note
Hybridization position of the probes on the chromosome. -
Applications
Fluorescent In Situ Hybridization (Cell)
Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
Human Ewing's sarcoma (FFPE) stained with EWSR1 Split FISH Probe. Human Ewing's sarcoma showed EWSR1 gene split.Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
Human myoepithelioma (FFPE) stained with EWSR1 Split FISH Probe. Human myoepithelioma showed EWSR1 gene split.Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
Human breast cancer (FFPE) stained with EWSR1 Split FISH Probe. Human breast cancer showed EWSR1 gene split. -
Gene Info — EWSR1
Entrez GeneID
2130Gene Name
EWSR1
Gene Alias
EWS
Gene Description
Ewing sarcoma breakpoint region 1
Omim ID
133450Gene Ontology
HyperlinkGene Summary
This gene encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. The protein includes an N-terminal transcriptional activation domain and a C-terminal RNA-binding domain. Chromosomal translocations between this gene and various genes encoding transcription factors result in the production of chimeric proteins that are involved in tumorigenesis. These chimeric proteins usually consist of the N-terminal transcriptional activation domain of this protein fused to the C-terminal DNA-binding domain of the transcription factor protein. Mutations in this gene, specifically a t(11;22)(q24;q12) translocation, are known to cause Ewing sarcoma as well as neuroectodermal and various other tumors. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and 14. [provided by RefSeq
Other Designations
Ewings sarcoma EWS-Fli1 (type 1) oncogene|bK984G1.4 (Ewing sarcoma breakpoint region 1 protein)
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Interactome
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Publication Reference
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Detection of SYT and EWS gene rearrangements by dual-color break-apart CISH in liquid-based cytology samples of synovial sarcoma and Ewing sarcoma/primitive neuroectodermal tumor.
Kumagai A, Motoi T, Tsuji K, Imamura T, Fukusato T.
American Journal of Clinical Pathology 2010 Aug; 134(2):323.
Application：FISH, Human, Ewing sarcoma.
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Detection of SYT and EWS gene rearrangements by dual-color break-apart CISH in liquid-based cytology samples of synovial sarcoma and Ewing sarcoma/primitive neuroectodermal tumor.
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