mutaFISH™ MYCNwt DNA Probes
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More Files
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mutation specific, Fluorescence In Situ Hybridization (Cells)
mutaFISH™ staining was performed in situ in human SK-N-BE(2) cells captured by CytoQuest™ CR. MYCN amplification was detected via red signal (Cy5).
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Specification
Product Description
mutaFISH™ MYCNwt DNA Probes is designed to identify human MYCN gene amplification on dsDNA in cells using padlock probe and in situ rolling-circle amplification technology.
Reactivity
Human
Supplied Product
Content:
1. mutaFISH™ MYCNwt DNA Probe
2. Detection Probe-Texas Red XComparison
Fluorophore
Texas Red X (Excitation Peak (nm): 595; Emission Peak 613)
Probe Position
Regulatory Status
For research use only (RUO)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
We recommend mutaFISH™ DNA Accessory Kit 1 for Cells (Catalog #: KA4916) which provides necessary reagents and enzymes for in situ restriction digestion, exonucleolysis, mutaFISH™ hybridization, ligation and amplification prior to mutaFISH™.
Video
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Applications
mutation specific, Fluorescence In Situ Hybridization (Cells)
mutaFISH™ staining was performed in situ in human SK-N-BE(2) cells captured by CytoQuest™ CR. MYCN amplification was detected via red signal (Cy5). -
Gene Info — MYCN
Entrez GeneID
4613Gene Name
MYCN
Gene Alias
MODED, N-myc, NMYC, ODED, bHLHe37
Gene Description
v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)
Gene Ontology
HyperlinkGene Summary
This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas. [provided by RefSeq
Other Designations
N-myc proto-oncogene protein|neuroblastoma MYC oncogene|neuroblastoma-derived v-myc avian myelocytomatosis viral related oncogene|oncogene NMYC|pp65/67|v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived|v-myc myelocytomatosis viral
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Interactome
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Disease
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