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mutaFISH™ MYCNwt DNA Probes

  • Catalog # : FP0003
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  • Specification
  • Product Description:
  • mutaFISH™ MYCNwt DNA Probes is designed to identify human MYCN gene amplification on dsDNA in cells using in situ rolling-circle amplication technology.
  • Supplied Product:
  • Content:

    1. mutaFISH™ MYCNwt DNA Probe

    2. Detection Probe-Cy5
  • Storage Instruction:
  • Store at -20°C.
  • Note:
  • We recommend mutaFISH™ DNA Accessory Kit 1 for Cell (Catalog #: KA4916) which provides necessary reagents and enzymes for in situ restriction digestion, exonucleolysis, mutaFISH™ hybridization, ligation and amplification prior to mutaFISH™.
  • Fluorophore:
  • Cy5 (Excitation Peak (nm): 650; Emission Peak (nm): 670)
  • Probe Position:
  • Regulatory Status:
  • For research use only (RUO)
  • Applications
  • mutation specific, Fluorescence In Situ Hybridization (Cells)
  • mutation specific, Fluorescence <em>In Situ</em> Hybridization (Cells)
  • mutaFISH™ staining was performed in situ in human SK-N-BE(2) cells captured by CytoQuest™ CR. MYCN amplification was detected via red signal (Cy5).
  • Application Image
  • mutation specific, Fluorescence In Situ Hybridization (Cells)
  • mutation specific, Fluorescence <em>In Situ</em> Hybridization (Cells)
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  • Gene Information
  • Entrez GeneID:
  • 4613
  • Gene Name:
  • MYCN
  • Gene Alias:
  • MODED,N-myc,NMYC,ODED,bHLHe37
  • Gene Description:
  • v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)
  • Gene Summary:
  • This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas. [provided by RefSeq
  • Other Designations:
  • N-myc proto-oncogene protein,neuroblastoma MYC oncogene,neuroblastoma-derived v-myc avian myelocytomatosis viral related oncogene,oncogene NMYC,pp65/67,v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived,v-myc myelocytomatosis viral
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