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mutaFISH™ EGFR T790M T790wt RNA Probes

  • Catalog # : FP0001
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  • Specification
  • Product Description:
  • mutaFISH™ EGFR T790M T790wt RNA Probes is designed to detect human EGFR T790M gene mutation on single strand RNA in cells using in situ rolling-circle amplication technology.
  • Supplied Product:
  • Content:

    1. RT EGFR T790 Primer

    2. mutaFISH™ EGFR T790M RNA Probe

    3. mutaFISH™ EGFR T790wt RNA Probe

    4. Detection Probe-Cy5

    5. Detection Probe-Cy3
  • Storage Instruction:
  • Store at -20°C.
  • Note:
  • We recommend mutaFISH™ RNA Accessory Kit (Catalog #: KA4915) which provides necessary reagents and enzymesfor in situ reverse transcription, RNA digestion, mutaFISH™ hybridization, ligation and amplication prior to mutaFISH™.
  • Fluorophore:
  • Cy3 (Excitation wavelength: 548; Emission wavelength: 561)
    Cy5 (Excitation wavelength: 647; Emission wavelength: 665)
  • Probe Position:
  • Regulatory Status:
  • For research use only (RUO)
  • Applications
  • mutation specific, Fluorescence In Situ Hybridization
  • mutation specific, Fluorescence <em>In Situ</em> Hybridization
  • mutaFISH™ staining was performed in situ in human H1975 cells captured by CytoQuest™ CR. EGFR T790M point mutation was detected via orange signal (Cy3), and EGFR T790wt was detected via red signal (Cy5).
  • Application Image
  • mutation specific, Fluorescence In Situ Hybridization
  • mutation specific, Fluorescence <em>In Situ</em> Hybridization
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  • Gene Information
  • Entrez GeneID:
  • 1956
  • Gene Name:
  • EGFR
  • Gene Alias:
  • Gene Description:
  • epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)
  • Gene Summary:
  • The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. [provided by RefSeq
  • Other Designations:
  • avian erythroblastic leukemia viral (v-erb-b) oncogene homolog,cell growth inhibiting protein 40,cell proliferation-inducing protein 61,epidermal growth factor receptor
  • Interactome
  • Interactome
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