Products

Fluorescent In Situ Hybridization (Cell)

Entrez GeneID

Gene Name

PPM1D

Gene Alias

PP2C-DELTA, WIP1

Gene Description

protein phosphatase 1D magnesium-dependent, delta isoform

Omim ID

Gene Ontology

Gene Summary

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development. [provided by RefSeq

Other Designations

p53-induced protein phosphatase 1|protein phosphatase 1D|protein phosphatase 2C delta isoform|protein phosphatase Wip1