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Last updated: 2020/11/29

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PPM1D/CEN17qFISH Probe 

  • Catalog # : FG0238
  • Visit Frequency :
  • Countries :
  • Specification
  • Product Description:
  • Labeled FISH probes for identification of gene amplification using Fluoresecent In Situ Hybridization Technique. (Technology)
  • Reactivity:
  • Human
  • Quality Control Testing:
  • Representative images of normal human cell (lymphocyte) stain with the dual color FISH probe. The left image is chromosomes at metaphase, and the right image is an interphase nucleus.

    QC Testing of FG0238
  • Supplied Product:
  • DAPI Counterstain (1500 ng/mL ) 125 uL for each 100 uL FISH Probe
  • Storage Instruction:
  • Store at 4°C in the dark.
  • Note:
  • Hybridization position of the probes on the chromosome.

  • Probe 1:
        Size:
        Fluorophore:
        Location:
  • PPM1D
    Approximately 300kb
    Texas Red
    17q23.2
  • Probe 2:
        Size:
        Fluorophore:
        Location:
  • CEN17q
    Approximately 540kb
    FITC
    17q11.2
  • Origin:
  • Human
  • Source:
  • Genomic DNA
  • Notice:
  • We strongly recommend the customer to use FFPE FISH PreTreatment Kit 1 (Catalog #: KA2375 or KA2691) for the pretreatment of Formalin-Fixed Paraffin-Embedded (FFPE) tissue sections.
  • Regulatory Status:
  • For research use only (RUO)
  • Applications
  • Application Image
  • Fluorescent In Situ Hybridization (Cell)
  • Gene Information
  • Entrez GeneID:
  • 8493
  • Gene Name:
  • PPM1D
  • Gene Alias:
  • PP2C-DELTA,WIP1
  • Gene Description:
  • protein phosphatase 1D magnesium-dependent, delta isoform
  • Gene Summary:
  • The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development. [provided by RefSeq
  • Other Designations:
  • p53-induced protein phosphatase 1,protein phosphatase 1D,protein phosphatase 2C delta isoform,protein phosphatase Wip1
  • Gene Pathway
  • Related Disease
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