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Last updated: 2016/10/23

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  • Catalog # : FG0177
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  • Specification
  • Product Description:
  • Labeled FISH probes for identification of gene amplification using Fluoresecent In Situ Hybridization Technique. (Technology)
  • Quality Control Testing:
  • Representative images of normal human cell (lymphocyte) stain with the dual color FISH probe. The left image is chromosomes at metaphase, and the right image is an interphase nucleus.

    QC Testing of FG0177
  • Supplied Product:
  • DAPI Counterstain (1500 ng/mL ) 250 uL
  • Storage Instruction:
  • Store at 4°C in the dark.
  • Note:
  • Hybridization position of the probes on the chromosome:

  • Probe 1:
  • CDKN2D
    Approximately 170kb
    Texas Red
  • Probe 2:
  • CEN19p
    Approximately 570kb
  • Origin:
  • Human
  • Source:
  • Genomic DNA
  • Notice:
  • We strongly recommend the customer to use FFPE FISH PreTreatment Kit 1 (Catalog #: KA2375 or KA2691) for the pretreatment of Formalin-Fixed Paraffin-Embedded (FFPE) tissue sections.
  • Regulation Status:
  • For research use only (RUO)
  • Applications
  • Application Image
  • Fluorescent In Situ Hybridization (Cell)
  • Gene Information
  • Entrez GeneID:
  • 1032
  • Gene Name:
  • CDKN2D
  • Gene Alias:
  • INK4D,p19,p19-INK4D
  • Gene Description:
  • cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
  • Gene Summary:
  • The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to form a stable complex with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. The abundance of the transcript of this gene was found to oscillate in a cell-cycle dependent manner with the lowest expression at mid G1 and a maximal expression during S phase. The negative regulation of the cell cycle involved in this protein was shown to participate in repressing neuronal proliferation, as well as spermatogenesis. Two alternatively spliced variants of this gene, which encode an identical protein, have been reported. [provided by RefSeq
  • Other Designations:
  • CDK inhibitor p19INK4d,cell cycle inhibitor, Nur77 associating protein,cyclin-dependent kinase 4 inhibitor D p19,cyclin-dependent kinase inhibitor 2D,inhibitor of cyclin-dependent kinase 4d
  • Gene Pathway
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