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AR/CENXp FISH Probe

  • Catalog # : FG0163
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  • Specification
  • Product Description:
  • Labeled FISH probes for identification of gene amplification using Fluoresecent In Situ Hybridization Technique.
  • Storage Instruction:
  • Store at 4°C in the dark.
  • Note:
  • Hybridization position of the probes on the chromosome.

  • Probe 1:
        Size:
        Fluorophore:
        Location:
  • AR
    Approximately 520 kb
    R6G
    Xq12
  • Probe 2:
        Size:
        Fluorophore:
        Location:
  • CENXp
    Approximately 400 kb
    FITC
    Xp11.21
  • Probe Gap:
  • The gap between two probes is approximately 11,000 kb
  • Origin:
  • Human
  • Source:
  • Genomic DNA
  • Regulation Status:
  • For research use only (RUO)
  • Applications
  • DNA Hybridization
  • DNA Hybridization enlargeenlarge this image
  • Human prostate cancer cells stained with AR/CENXp FISH Probe.
  • Application Image
  • Gene Information
  • Entrez GeneID:
  • 367
  • Gene Name:
  • AR
  • Gene Alias:
  • AIS,DHTR,HUMARA,KD,NR3C4,SBMA,SMAX1,TFM
  • Gene Description:
  • androgen receptor
  • Gene Summary:
  • The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq
  • Other Designations:
  • OTTHUMP00000023450,OTTHUMP00000061928,dihydrotestosterone receptor
  • Related Disease
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