HMGA2/CEN12q FISH Probe
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More Files
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Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
human ovary cancer (FFPE) stained with HMGA2/CEN12q FISH Probe . human ovary cancer showed no HMGA2 amplification.
Hybridization position of the probes on the chromosome.
Hybridization position of the probes on the chromosome.
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Specification
Product Description
Labeled FISH probes for identification of gene amplification using Fluorescent In Situ Hybridization Technique. (Technology).
Probe 1
Name: HMGA2
Size: Approximately 430kb
Fluorophore: Texas Red
Location: 12q15Probe 2
Name: CEN12q
Size: Approximately 580kb
Fluorophore: FITC
Location: 12q12Probe Gap
The gap between two probes is approximately 22,100 kb.
Origin
Human
Source
Genomic DNA
Reactivity
Human
Form
Liquid
Notice
We strongly recommend the customer to use FFPE FISH PreTreatment Kit 1 (Catalog #: KA2375 or KA2691) for the pretreatment of Formalin-Fixed Paraffin-Embedded (FFPE) tissue sections.
Regulation Status
For research use only (RUO)
Quality Control Testing
Representative images of normal human cell (lymphocyte) stain with the dual color FISH probe. The left image is chromosomes at metaphase, and the right image is an interphase nucleus.
Supplied Product
DAPI Counterstain (1500 ng/mL ) 125 uL for each 100 uL FISH Probe
Storage Instruction
Store at 4°C in the dark.
Note
Hybridization position of the probes on the chromosome.
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Applications
Fluorescent In Situ Hybridization (Cell)
Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
human ovary cancer (FFPE) stained with HMGA2/CEN12q FISH Probe . human ovary cancer showed no HMGA2 amplification. -
Gene Info — HMGA2
Entrez GeneID
8091Gene Name
HMGA2
Gene Alias
BABL, HMGI-C, HMGIC, LIPO, STQTL9
Gene Description
high mobility group AT-hook 2
Gene Ontology
HyperlinkGene Summary
This gene encodes a protein that belongs to the non-histone chromosomal high mobility group (HMG) protein family. HMG proteins function as architectural factors and are essential components of the enhancesome. This protein contains structural DNA-binding domains and may act as a transcriptional regulating factor. Identification of the deletion, amplification, and rearrangement of this gene that are associated with myxoid liposarcoma suggests a role in adipogenesis and mesenchymal differentiation. A gene knock out study of the mouse counterpart demonstrated that this gene is involved in diet-induced obesity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq
Other Designations
High-mobility group protein HMGI-C|high-mobility group (nonhistone chromosomal) protein isoform I-C
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Interactome
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Disease
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