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Last updated: 2016/12/4

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BRCA2/CEN13q FISH Probe

  • Catalog # : FG0135
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  • Specification
  • Product Description:
  • Labeled FISH probes for identification of gene amplification using Fluoresecent In Situ Hybridization Technique. (Technology)
  • Quality Control Testing:
  • Representative images of normal human cell (lymphocyte) stain with the dual color FISH probe. The left image is chromosomes at metaphase, and the right image is an interphase nucleus.

    QC Testing of FG0135
  • Supplied Product:
  • DAPI Counterstain (1500 ng/mL ) 250 uL
  • Storage Instruction:
  • Store at 4°C in the dark.
  • Note:
  • Hybridization position of the probes on the chromosome.

  • Probe 1:
        Size:
        Fluorophore:
        Location:
  • BRCA2
    Approximately 170kb
    Texas Red
    13q13.1
  • Probe 2:
        Size:
        Fluorophore:
        Location:
  • CEN13q
    Approximately 550kb
    FITC
    13q12.11
  • Probe Gap:
  • The gap between two probes is approximately 4,670 kb.
  • Origin:
  • Human
  • Source:
  • Genomic DNA
  • Notice:
  • We strongly recommend the customer to use FFPE FISH PreTreatment Kit 1 (Catalog #: KA2375 or KA2691) for the pretreatment of Formalin-Fixed Paraffin-Embedded (FFPE) tissue sections.
  • Regulation Status:
  • For research use only (RUO)
  • Applications
  • Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
  • Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections) enlargeenlarge this image
  • human tonsil (FFPE) stained with BRCA2/CEN13q FISH Probe. human tonsil showed no BRCA2 amplification.
  • PDF DownloadProtocol Download
  • Application Image
  • Fluorescent In Situ Hybridization (Cell)
  • Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
  • Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
  • enlarge
  • Gene Information
  • Entrez GeneID:
  • 675
  • Gene Name:
  • BRCA2
  • Gene Alias:
  • BRCC2,FACD,FAD,FAD1,FANCB,FANCD,FANCD1
  • Gene Description:
  • breast cancer 2, early onset
  • Gene Summary:
  • Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele. [provided by RefSeq
  • Other Designations:
  • BRCA1/BRCA2-containing complex, subunit 2,OTTHUMP00000018803,OTTHUMP00000042401,breast and ovarian cancer susceptibility gene, early onset,breast cancer 2 tumor suppressor,breast cancer susceptibility protein BRCA2
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