BRCA2/CEN13q FISH Probe
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Specifications
Product Description
Labeled FISH probes for identification of gene amplification using Fluorescent In Situ Hybridization Technique. (Technology).
Probe 1
Name: BRCA2
Size: Approximately 170kb
Fluorophore: Texas Red
Location: 13q13.1Probe 2
Name: CEN13q
Size: Approximately 550kb
Fluorophore: FITC
Location: 13q12.11Probe Gap
The gap between two probes is approximately 4,670 kb.
Origin
Human
Source
Genomic DNA
Reactivity
Human
Form
Liquid
Notice
We strongly recommend the customer to use FFPE FISH PreTreatment Kit 1 (Catalog #: KA2375 or KA2691) for the pretreatment of Formalin-Fixed Paraffin-Embedded (FFPE) tissue sections.
Regulation Status
For research use only (RUO)
Quality Control Testing
Representative images of normal human cell (lymphocyte) stain with the dual color FISH probe. The left image is chromosomes at metaphase, and the right image is an interphase nucleus.
Supplied Product
DAPI Counterstain (1500 ng/mL ) 125 uL for each 100 uL FISH Probe
Storage Instruction
Store at 4°C in the dark.
Note
Hybridization position of the probes on the chromosome.
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Applications
Fluorescent In Situ Hybridization (Cell)
Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
human tonsil (FFPE) stained with BRCA2/CEN13q FISH Probe. human tonsil showed no BRCA2 amplification. -
Gene Info — BRCA2
Entrez GeneID
675Gene Name
BRCA2
Gene Alias
BRCC2, FACD, FAD, FAD1, FANCB, FANCD, FANCD1
Gene Description
breast cancer 2, early onset
Gene Ontology
HyperlinkGene Summary
Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele. [provided by RefSeq
Other Designations
BRCA1/BRCA2-containing complex, subunit 2|OTTHUMP00000018803|OTTHUMP00000042401|breast and ovarian cancer susceptibility gene, early onset|breast cancer 2 tumor suppressor|breast cancer susceptibility protein BRCA2
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Interactomes
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Diseases
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