Labeled FISH probes for identification of gene amplification using Fluoresecent In Situ Hybridization Technique.
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Representative images of human lung cancer cell stain with the dual color FISH probe. The left image is two copies of EGFR gene and two copies of chromosome 7 in cell (normal); and the right image is two copies of chromosome 7, higher copy number of EGFR gene (amplification).
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Hybridization position of the probes on the chromosome.
The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. [provided by RefSeq
avian erythroblastic leukemia viral (v-erb-b) oncogene homolog,cell growth inhibiting protein 40,cell proliferation-inducing protein 61,epidermal growth factor receptor