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Last updated: 2017/6/18

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RARA (Orange) FISH ProbeGMP

  • Catalog # : FG0101
  • Visit Frequency :
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  • Specification
  • Product Description:
  • Labeled FISH probes for identification of gene amplification using Fluoresecent In Situ Hybridization Technique.
  • Quality Control Testing:
  • Representative images of human breast cancer cell stain with the dual color FISH probe. The left image is stained with RARA (Orange) FISH Probe/CEP17 (Green) shows 2 orange signals of the RARA gene and 2 green signals of chromosome 17; and the right image is n abnormal cell hybridized with the RARA (Orange) FISH probe showing more than 20 orange signals which indicate the amplification of RARA gene.

    QC Testing of FG0101
  • Storage Instruction:
  • Store at -20°C in the dark.
  • Note:
  • Hybridization position of the probes on the chromosome.

  • Probe 1:
        Size:
        Fluorophore:
        Location:
  • RARA
    Approximately 169kb
    Orange
    17q21
  • Origin:
  • Human
  • Source:
  • Genomic DNA
  • Regulation Status:
  • For research use only (RUO)
  • Applications
  • Application Image
  • Fluorescent In Situ Hybridization
  • Gene Information
  • Entrez GeneID:
  • 5914
  • Gene Name:
  • RARA
  • Gene Alias:
  • NR1B1,RAR
  • Gene Description:
  • retinoic acid receptor, alpha
  • Gene Summary:
  • Retinoid signaling is transduced by 2 families of nuclear receptors, retinoic acid receptor (RAR) and retinoid X receptor (RXR; see MIM 180245), which form RXR/RAR heterodimers. In the absence of ligand, DNA-bound RXR/RARA represses transcription by recruiting the corepressors NCOR1 (MIM 600849), SMRT (NCOR2; MIM 600848), and histone deacetylase (see MIM 601241). When ligand binds to the complex, it induces a conformational change allowing the recruitment of coactivators, histone acetyltransferases (see MIM 603053), and the basic transcription machinery. Translocations that always involve rearrangement of the RARA gene are a cardinal feature of acute promyelocytic leukemia (APL; MIM 612376). The most frequent translocation is t(15,17)(q21;q22), which fuses the RARA gene with the PML gene (MIM 102578) (Vitoux et al., 2007 [PubMed 17468032]).[supplied by OMIM
  • Other Designations:
  • OTTHUMP00000164454,OTTHUMP00000164456,Retinoic acid receptor, alpha polypeptide,nucleophosmin-retinoic acid receptor alpha fusion protein NPM-RAR long form
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