Labeled FISH probes for identification of gene amplification using Fluoresecent In Situ Hybridization Technique.
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Representative images of neuroblastoma patient tissue stain with the FISH probe. The left image is two signals of MYCN gene (Orange) in a normal cell; the right image is higher copy number of MYCN gene (amplification) without chromosome enumeration probe.
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Hybridization position of the probes on the chromosome.
This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas. [provided by RefSeq