Labeled FISH probes for identification of gene amplification using Fluoresecent In Situ Hybridization Technique.
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Representative images of human cell stain with the FISH probe. The left image is two copies of MYC gene in HL60S cell line; the right image is higher copy number of MYC gene in NCiN417 cell line without chromosome enumeration probe.
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Hybridization position of the probes on the chromosome.
The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. [provided by RefSeq