BAP1/CEN3q FISH Probe
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Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
Human lung adenocarcinoma (FFPE) stained with BAP1/CEN3q FISH Probe. Human lung adenocarcinoma showed no BAP1 gene amplification.
Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
Human prostate cancer (FFPE) stained with BAP1/CEN3q FISH Probe. Human prostate cancer showed BAP1 gene amplification.
Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
Human pancreatic cancer (FFPE) stained with BAP1/CEN3q FISH Probe. Human pancreatic cancer showed no BAP1 gene amplification.
Hybridization position of the probes on the chromosome:
Hybridization position of the probes on the chromosome:
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Specification
Product Description
Labeled FISH probes for identification of gene amplification using Fluorescent In Situ Hybridization Technique. (Technology).
Probe 1
Name: BAP1
Size: Approximately 150kb
Fluorophore: TexRed
Location: 3p21.1Probe 2
Name: CEN3q
Size: Approximately 500kb
Fluorophore: FITC
Location: 3q12.1Probe Gap
The gap between two probes is approximately 43080 kb.
Origin
Human
Source
Genomic DNA
Reactivity
Human
Form
Liquid
Notice
We strongly recommend the customer to use FFPE FISH PreTreatment Kit 1 (Catalog #: KA2375 or KA2691) for the pretreatment of Formalin-Fixed Paraffin-Embedded (FFPE) tissue sections.
Regulation Status
For research use only (RUO)
Quality Control Testing
Representative images of normal human cell (lymphocyte) stain with the dual color FISH probe. The left image is chromosomes at metaphase, and the right image is an interphase nucleus.
Supplied Product
DAPI Counterstain (1500 ng/mL ) 125 uL for each 100 uL FISH Probe
Storage Instruction
Store at 4°C in the dark.
Note
Hybridization position of the probes on the chromosome:
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Applications
Fluorescent In Situ Hybridization (Cell)
Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
Human lung adenocarcinoma (FFPE) stained with BAP1/CEN3q FISH Probe. Human lung adenocarcinoma showed no BAP1 gene amplification.Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
Human prostate cancer (FFPE) stained with BAP1/CEN3q FISH Probe. Human prostate cancer showed BAP1 gene amplification.Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
Human pancreatic cancer (FFPE) stained with BAP1/CEN3q FISH Probe. Human pancreatic cancer showed no BAP1 gene amplification. -
Gene Info — BAP1
Entrez GeneID
8314Gene Name
BAP1
Gene Alias
DKFZp686N04275, FLJ35406, FLJ37180, HUCEP-13, KIAA0272, UCHL2, hucep-6
Gene Description
BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
Omim ID
603089Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene localizes to the nucleus and it interacts with the RING finger domain of the breast cancer 1, early onset protein (BRCA1). This gene is thought to be a tumor suppressor gene that functions in the BRCA1 growth control pathway. There are multiple polyadenylation sites found in this gene. [provided by RefSeq
Other Designations
BRCA1 associated protein-1|cerebral protein-13|cerebral protein-6|ubiquitin carboxy-terminal hydrolase
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Interactome
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Disease
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Publication Reference
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Sensitivity to asbestos is increased in patients with mesothelioma and pathogenic germline variants in BAP1 or other DNA repair genes.
Betti M, Aspesi A, Ferrante D, Sculco M, Righi L, Mirabelli D, Napoli F, Rondón-Lagos M, Casalone E, Vignolo Lutati F, Ogliara P, Bironzo P, Gironi CL, Savoia P, Maffè A, Ungari S, Grosso F, Libener R, Boldorini R, Valiante M, Pasini B, Matullo G, Scagliotti G, Magnani C, Dianzani I.
Genes, Chromosomes & Cancer 2018 Nov; 57(11):573.
Application：FISH, Human, Human malignant pleural mesothelioma, Pleural effusion cells.
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BAP1 (BRCA1-associated protein 1) is a highly specific marker for differentiating mesothelioma from reactive mesothelial proliferations.
Cigognetti M, Lonardi S, Fisogni S, Balzarini P, Pellegrini V, Tironi A, Bercich L, Bugatti M, Rossi G, Murer B, Barbareschi M, Giuliani S, Cavazza A, Marchetti G, Vermi W, Facchetti F.
Modern Pathology 2015 Aug; 28(8):1043.
Application：FISH, Human, Mesothelioma.
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Sensitivity to asbestos is increased in patients with mesothelioma and pathogenic germline variants in BAP1 or other DNA repair genes.
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