CTTN/CEN11p FISH Probe
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Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
Human breast cancer (FFPE) stained with EMS1/CEN11p FISH Probe. Human breast cancer showed EMS1 gene amplification.
Hybridization position of the probes on the chromosome:
Hybridization position of the probes on the chromosome:
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Specification
Product Description
Labeled FISH probes for identification of gene amplification using Fluorescent In Situ Hybridization Technique. (Technology).
Probe 1
Name: CTTN
Size: Approximately 470kb
Fluorophore: TexRed
Location: 11q13.3Probe 2
Name: CEN11p
Size: Approximately 630kb
Fluorophore: FITC
Location: 11p11.12Probe Gap
The gap between two probes is approximately 22460 kb.
Origin
Human
Source
Genomic DNA
Reactivity
Human
Form
Liquid
Notice
We strongly recommend the customer to use FFPE FISH PreTreatment Kit 1 (Catalog #: KA2375 or KA2691) for the pretreatment of Formalin-Fixed Paraffin-Embedded (FFPE) tissue sections.
Regulation Status
For research use only (RUO)
Quality Control Testing
Representative images of normal human cell (lymphocyte) stain with the dual color FISH probe. The left image is chromosomes at metaphase, and the right image is an interphase nucleus.
Supplied Product
DAPI Counterstain (1500 ng/mL ) 125 uL for each 100 uL FISH Probe
Storage Instruction
Store at 4°C in the dark.
Note
Hybridization position of the probes on the chromosome:
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Applications
Fluorescent In Situ Hybridization (Cell)
Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
Human breast cancer (FFPE) stained with EMS1/CEN11p FISH Probe. Human breast cancer showed EMS1 gene amplification. -
Gene Info — CTTN
Entrez GeneID
2017Gene Name
CTTN
Gene Alias
EMS1, FLJ34459
Gene Description
cortactin
Omim ID
164765Gene Ontology
HyperlinkGene Summary
This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Two splice variants that encode different isoforms have been identified for this gene. [provided by RefSeq
Other Designations
1110020L01Rik|ems1 sequence (mammary tumor and squamous cell carcinoma-associated (p80/85 src substrate)|oncogene EMS1
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Interactome
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Disease
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