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Last updated: 2017/7/23

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SQSTM1/CEN5q FISH Probe

  • Catalog # : FG0064
  • Visit Frequency :
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  • Specification
  • Product Description:
  • Labeled FISH probes for identification of gene amplification using Fluoresecent In Situ Hybridization Technique. (Technology)
  • Quality Control Testing:
  • Representative images of normal human cell (lymphocyte) stain with the dual color FISH probe. The left image is chromosomes at metaphase, and the right image is an interphase nucleus.

    QC Testing of FG0064
  • Supplied Product:
  • DAPI Counterstain (1500 ng/mL ) 250 uL
  • Storage Instruction:
  • Store at 4°C in the dark.
  • Note:
  • Hybridization position of the probes on the chromosome:

  • Probe 1:
        Size:
        Fluorophore:
        Location:
  • SQSTM1
    Approximately 350kb
    Texas Red
    5q35.3
  • Probe 2:
        Size:
        Fluorophore:
        Location:
  • CEN5q
    Approximately 700kb
    FITC
    5q11.2
  • Probe Gap:
  • The gap between two probes is approximately 126,300 kb.
  • Origin:
  • Human
  • Source:
  • Genomic DNA
  • Notice:
  • We strongly recommend the customer to use FFPE FISH PreTreatment Kit 1 (Catalog #: KA2375 or KA2691) for the pretreatment of Formalin-Fixed Paraffin-Embedded (FFPE) tissue sections.
  • Regulation Status:
  • For research use only (RUO)
  • Applications
  • Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
  • Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections) enlargeenlarge this image
  • Human breast cancer (FFPE) stained with SQSTM1/CEN5q FISH Probe. Human breast cancer showed no SQSTM1 gene amplification
  • PDF DownloadProtocol Download
  • Application Image
  • Fluorescent In Situ Hybridization (Cell)
  • Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
  • Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
  • enlarge
  • Gene Information
  • Entrez GeneID:
  • 8878
  • Gene Name:
  • SQSTM1
  • Gene Alias:
  • A170,OSIL,PDB3,ZIP3,p60,p62,p62B
  • Gene Description:
  • sequestosome 1
  • Gene Summary:
  • This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone. [provided by RefSeq
  • Other Designations:
  • EBI3-associated protein p60,Paget disease of bone 3,oxidative stress induced like,phosphotyrosine independent ligand for the Lck SH2 domain p62,ubiquitin-binding protein p62
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