ATP7A/CENXp FISH Probe
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More Files
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Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
Human ovary cancer (FFPE) stained with ATP7A/CENXp FISH Probe. Human ovary cancer showed no ATP7A gene amplification.
Hybridization position of the probes on the chromosome:
Hybridization position of the probes on the chromosome:
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Specification
Product Description
Labeled FISH probes for identification of gene amplification using Fluorescent In Situ Hybridization Technique. (Technology).
Probe 1
Name: ATP7A
Size: Approximately 350kb
Fluorophore: Texas Red
Location: Xq21.1Probe 2
Name: CENXp
Size: Approximately 550kb
Fluorophore: FITC
Location: Xp11.22Probe Gap
The gap between two probes is approximately 27,500 kb.
Origin
Human
Source
Genomic DNA
Reactivity
Human
Form
Liquid
Notice
We strongly recommend the customer to use FFPE FISH PreTreatment Kit 1 (Catalog #: KA2375 or KA2691) for the pretreatment of Formalin-Fixed Paraffin-Embedded (FFPE) tissue sections.
Regulation Status
For research use only (RUO)
Quality Control Testing
Representative images of normal human cell (lymphocyte) stain with the dual color FISH probe. The left image is chromosomes at metaphase, and the right image is an interphase nucleus.
Supplied Product
DAPI Counterstain (1500 ng/mL ) 125 uL for each 100 uL FISH Probe
Storage Instruction
Store at 4°C in the dark.
Note
Hybridization position of the probes on the chromosome:
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Applications
Fluorescent In Situ Hybridization (Cell)
Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
Human ovary cancer (FFPE) stained with ATP7A/CENXp FISH Probe. Human ovary cancer showed no ATP7A gene amplification. -
Gene Info — ATP7A
Entrez GeneID
538Gene Name
ATP7A
Gene Alias
FLJ17790, MK, MNK
Gene Description
ATPase, Cu++ transporting, alpha polypeptide
Gene Ontology
HyperlinkGene Summary
This gene encodes a transmembrane protein that functions in copper transport across membranes. The protein localizes to the trans-Golgi network, where it is predicted to supply copper to copper-dependent enzymes in the secretory pathway. The protein relocalizes to the plasma membrane under conditions of elevated extracellular copper and functions in the efflux of copper from cells. Mutations in this gene result in Menkes disease, X-linked cutis laxa, and occipital horn syndrome. [provided by RefSeq
Other Designations
Cu++-transporting P-type ATPase|Menkes disease-associated protein|Menkes syndrome|OTTHUMP00000023593|OTTHUMP00000062077|copper pump 1|copper-transporting ATPase 1
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