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MDM4/CEN1q FISH Probe

  • Catalog # : FG0054
  • Visit Frequency :
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  • Specification
  • Product Description:
  • Labeled FISH probes for identification of gene amplification using Fluoresecent In Situ Hybridization Technique. (Technology)
  • Quality Control Testing:
  • Representative images of normal human cell (lymphocyte) stain with the dual color FISH probe. The left image is chromosomes at metaphase, and the right image is an interphase nucleus.

    QC Testing of FG0054
  • Supplied Product:
  • DAPI Counterstain (1500 ng/mL ) 250 uL
  • Storage Instruction:
  • Store at 4°C in the dark.
  • Note:
  • Hybridization position of the probes on the chromosome:

  • Probe 1:
        Size:
        Fluorophore:
        Location:
  • MDM4
    Approximately 350kb
    Texas Red
    1q32
  • Probe 2:
        Size:
        Fluorophore:
        Location:
  • CEN1q
    Approximately 600kb
    FITC
    1q21.3
  • Probe Gap:
  • The gap between two probes is approximately 49,700 kb.
  • Origin:
  • Human
  • Source:
  • Genomic DNA
  • Notice:
  • We strongly recommend the customer to use FFPE FISH PreTreatment Kit 1 (Catalog #: KA2375 or KA2691) for the pretreatment of Formalin-Fixed Paraffin-Embedded (FFPE) tissue sections.
  • Regulation Status:
  • For research use only (RUO)
  • Applications
  • Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
  • Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections) enlargeenlarge this image
  • Huma lung, adenosquamous cell carcinoma (FFPE) stained with MDM4/CEN1q FISH Probe. Human lung, adenosquamous cell carcinoma showed no MDM gene amplification.
  • PDF DownloadProtocol Download
  • Application Image
  • Fluorescent In Situ Hybridization (Cell)
  • Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
  • Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
  • enlarge
  • Gene Information
  • Entrez GeneID:
  • 4194
  • Gene Name:
  • MDM4
  • Gene Alias:
  • DKFZp781B1423,HDMX,MDMX,MGC132766,MRP1
  • Gene Description:
  • Mdm4 p53 binding protein homolog (mouse)
  • Gene Summary:
  • The human MDM4 gene, which plays a role in apoptosis, encodes a 490-amino acid protein containing a RING finger domain and a putative nuclear localization signal. The MDM4 putative nuclear localization signal, which all Mdm proteins contain, is located in the C-terminal region of the protein. The mRNA is expressed at a high level in thymus and at lower levels in all other tissues tested. MDM4 protein produced by in vitro translation interacts with p53 via a binding domain located in the N-terminal region of the MDM4 protein. MDM4 shows significant structural similarity to p53-binding protein MDM2. Two transcript variants, one protein-coding and the other likely not to be protein-coding, have been found for this gene. [provided by RefSeq
  • Other Designations:
  • MDM4-related protein 1,Mdm4, transformed 3T3 cell double minute 4, p53 binding protein,double minute 4, human homolog of; p53-binding protein,mouse double minute 4 homolog,p53-binding protein
  • Gene Pathway
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