MDM4/CEN1q FISH Probe
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Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
Huma lung, adenosquamous cell carcinoma (FFPE) stained with MDM4/CEN1q FISH Probe. Human lung, adenosquamous cell carcinoma showed no MDM gene amplification.
Hybridization position of the probes on the chromosome:
Hybridization position of the probes on the chromosome:
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Specification
Product Description
Labeled FISH probes for identification of gene amplification using Fluorescent In Situ Hybridization Technique. (Technology).
Probe 1
Name: MDM4
Size: Approximately 350kb
Fluorophore: Texas Red
Location: 1q32Probe 2
Name: CEN1q
Size: Approximately 600kb
Fluorophore: FITC
Location: 1q21.3Probe Gap
The gap between two probes is approximately 49,700 kb.
Origin
Human
Source
Genomic DNA
Reactivity
Human
Form
Liquid
Notice
We strongly recommend the customer to use FFPE FISH PreTreatment Kit 1 (Catalog #: KA2375 or KA2691) for the pretreatment of Formalin-Fixed Paraffin-Embedded (FFPE) tissue sections.
Regulation Status
For research use only (RUO)
Quality Control Testing
Representative images of normal human cell (lymphocyte) stain with the dual color FISH probe. The left image is chromosomes at metaphase, and the right image is an interphase nucleus.
Supplied Product
DAPI Counterstain (1500 ng/mL ) 125 uL for each 100 uL FISH Probe
Storage Instruction
Store at 4°C in the dark.
Note
Hybridization position of the probes on the chromosome:
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Applications
Fluorescent In Situ Hybridization (Cell)
Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
Huma lung, adenosquamous cell carcinoma (FFPE) stained with MDM4/CEN1q FISH Probe. Human lung, adenosquamous cell carcinoma showed no MDM gene amplification. -
Gene Info — MDM4
Entrez GeneID
4194Gene Name
MDM4
Gene Alias
DKFZp781B1423, HDMX, MDMX, MGC132766, MRP1
Gene Description
Mdm4 p53 binding protein homolog (mouse)
Omim ID
602704Gene Ontology
HyperlinkGene Summary
The human MDM4 gene, which plays a role in apoptosis, encodes a 490-amino acid protein containing a RING finger domain and a putative nuclear localization signal. The MDM4 putative nuclear localization signal, which all Mdm proteins contain, is located in the C-terminal region of the protein. The mRNA is expressed at a high level in thymus and at lower levels in all other tissues tested. MDM4 protein produced by in vitro translation interacts with p53 via a binding domain located in the N-terminal region of the MDM4 protein. MDM4 shows significant structural similarity to p53-binding protein MDM2. Two transcript variants, one protein-coding and the other likely not to be protein-coding, have been found for this gene. [provided by RefSeq
Other Designations
MDM4-related protein 1|Mdm4, transformed 3T3 cell double minute 4, p53 binding protein|double minute 4, human homolog of; p53-binding protein|mouse double minute 4 homolog|p53-binding protein
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