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Fluorescent In Situ Hybridization (Cell)

Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)

Human breast cancer (FFPE) stained with CXCL1/CEN4q FISH Probe. Human breast cancer showed no CXCL1 gene amplification

Entrez GeneID

2919

Gene Name

CXCL1

Gene Alias

FSP, GRO1, GROa, MGSA, MGSA-a, NAP-3, SCYB1

Gene Description

chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)

Omim ID

155730

Gene Ontology

Hyperlink

Gene Summary

Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC, based on the arrangement of the first 2 of the 4 conserved cysteine residues; the 2 cysteines are separated by a single amino acid in CXC chemokines and are adjacent in CC chemokines. CXC chemokines are further subdivided into ELR and non-ELR types based on the presence or absence of a glu-leu-arg sequence adjacent and N terminal to the CXC motif. ELR types are chemotactic for neutrophils, while non-ELR types are chemotactic for lymphocytes.[supplied by OMIM

Other Designations

GRO1 oncogene (melanoma growth stimulating activity, alpha)|GRO1 oncogene (melanoma growth-stimulating activity)|MGSA alpha|chemokine (C-X-C motif) ligand 1|fibroblast secretory protein|melanoma growth stimulatory activity alpha