MEN1/CEN11p FISH Probe
* The price is valid only in USA. Please select country.
-
More Files
- More Functions
Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
Huma lung, adenosquamous cell carcinoma (FFPE) stained with MEN1/CEN11p FISH Probe. Human lung, adenosquamous cell carcinoma showed no MEN1 gene amplification.
Hybridization position of the probes on the chromosome.
Hybridization position of the probes on the chromosome.
-
Specification
Product Description
Labeled FISH probes for identification of gene amplification using Fluorescent In Situ Hybridization Technique. (Technology).
Probe 1
Name: MEN1
Size: Approximately 500kb
Fluorophore: Texas Red
Location: 11q13Probe 2
Name: CEN11p
Size: Approximately 630kb
Fluorophore: FITC
Location: 11p11.12Probe Gap
The gap between two probes is approximately 16,700 kb
Origin
Human
Source
Genomic DNA
Reactivity
Human
Form
Liquid
Notice
We strongly recommend the customer to use FFPE FISH PreTreatment Kit 1 (Catalog #: KA2375 or KA2691) for the pretreatment of Formalin-Fixed Paraffin-Embedded (FFPE) tissue sections.
Regulation Status
For research use only (RUO)
Quality Control Testing
Representative images of normal human cell (lymphocyte) stain with the dual color FISH probe. The left image is chromosomes at metaphase, and the right image is an interphase nucleus.
Supplied Product
DAPI Counterstain (1500 ng/mL ) 125 uL for each 100 uL FISH Probe
Storage Instruction
Store at 4°C in the dark.
Note
Hybridization position of the probes on the chromosome. -
Applications
Fluorescent In Situ Hybridization (Cell)
Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
Huma lung, adenosquamous cell carcinoma (FFPE) stained with MEN1/CEN11p FISH Probe. Human lung, adenosquamous cell carcinoma showed no MEN1 gene amplification. -
Gene Info — MEN1
Entrez GeneID
4221Gene Name
MEN1
Gene Alias
MEAI, SCG2
Gene Description
multiple endocrine neoplasia I
Gene Ontology
HyperlinkGene Summary
This gene encodes menin, a putative tumor suppressor associated with a syndrome known as multiple endocrine neoplasia type 1. In vitro studies have shown menin is localized to the nucleus, possesses two functional nuclear localization signals, and inhibits transcriptional activation by JunD, however, the function of this protein is not known. Two messages have been detected on northern blots but the larger message has not been characterized. Alternative splicing results in multiple transcript variants. [provided by RefSeq
Other Designations
OTTHUMP00000042868|OTTHUMP00000070176|OTTHUMP00000070180|OTTHUMP00000070184|endocrine adenomatosis, multiple|menin
-
Interactome
-
Disease
-
Publication Reference
-
Syndromic MEN1 parathyroid adenomas consist of both subclonal nodules and clonally independent tumors.
Konstantin Bräutigam, Cédric Nesti, Philipp Riss, Christian Scheuba, Bruno Niederle, Tobias Grob, Annunziata Di Domenico, Maja Neuenschwander, Peter Mazal, Nastassja Köhn, Roman Trepp, Aurel Perren, Reto M Kaderli.
Virchows Archiv : an International Journal of Pathology 2024 Jan; [Epub].
Application：FISH, Human, parathyroid adenoma.
-
Syndromic MEN1 parathyroid adenomas consist of both subclonal nodules and clonally independent tumors.
- +1-909-264-1399
+1-909-992-0619
Toll Free : +1-877-853-6098 - +1-909-992-3401
- sales@abnova.com