Products

Fluorescent In Situ Hybridization (Cell)

Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)

Human breast cancer (FFPE) stained with HER3/CEN12p FISH Probe. Human breast cancer showed no HER3 gene amplification.

Entrez GeneID

2065

Gene Name

ERBB3

Gene Alias

ErbB-3, HER3, LCCS2, MDA-BF-1, MGC88033, c-erbB-3, c-erbB3, erbB3-S, p180-ErbB3, p45-sErbB3, p85-sErbB3

Gene Description

v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)

Omim ID

190151 607598

Gene Ontology

Hyperlink

Gene Summary

This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq

Other Designations

erbB-3|lethal congenital contracture syndrome 2|v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3