ACTN4/CEN19p FISH Probe
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More Files
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Hybridization position of the probes on the chromosome.
Hybridization position of the probes on the chromosome.
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Specification
Product Description
Labeled FISH probes for identification of gene amplification using Fluorescent In Situ Hybridization Technique. (Technology).
Probe 1
Name: ACTN4
Size: Approximately 210kb
Fluorophore: Texas Red
Location: 19q13Probe 2
Name: CEN19p
Size: Approximately 570kb
Fluorophore: FITC
Location: 19p13.11Probe Gap
The gap between two probes is approximately 17,000 kb.
Origin
Human
Source
Genomic DNA
Reactivity
Human
Notice
We strongly recommend the customer to use FFPE FISH PreTreatment Kit 1 (Catalog #: KA2375 or KA2691) for the pretreatment of Formalin-Fixed Paraffin-Embedded (FFPE) tissue sections.
Regulation Status
For research use only (RUO)
Quality Control Testing
Representative images of normal human cell (lymphocyte) stain with the dual color FISH probe. The left image is chromosomes at metaphase, and the right image is an interphase nucleus.
Supplied Product
DAPI Counterstain (1500 ng/mL ) 250 uL
Storage Instruction
Store at 4°C in the dark.
Note
Hybridization position of the probes on the chromosome. -
Applications
Fluorescent In Situ Hybridization (Cell)
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Gene Info — ACTN4
Entrez GeneID
81Gene Name
ACTN4
Gene Alias
ACTININ-4, DKFZp686K23158, FSGS, FSGS1
Gene Description
actinin, alpha 4
Gene Ontology
HyperlinkGene Summary
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis. [provided by RefSeq
Other Designations
actinin alpha4 isoform
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Interactome
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Pathway
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Disease
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Publication Reference
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Copy number gain of ACTN4 is associated with poor prognosis in patients with upper urinary tract urothelial carcinoma.
Kazuki Kawamura, Kosuke Miyai, Kimiya Sato, Susumu Matsukuma, Kazufumi Honda, Keiichi Ito, Hitoshi Tsuda.
Cancer Science 2023 Aug; 114(8):3411.
Application：FISH-P, Human, kidney, ureter.
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Copy number gain of ACTN4 is associated with poor prognosis in patients with upper urinary tract urothelial carcinoma.
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