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DYRK1A/CEN21q FISH Probe

  • Catalog # : FG0015
  • Visit Frequency :
  • Countries :
  • Specification
  • Product Description:
  • Labeled FISH probes for identification of gene amplification using Fluoresecent In Situ Hybridization Technique. (Technology)
  • Quality Control Testing:
  • Representative images of normal human cell (lymphocyte) stain with the dual color FISH probe. The left image is chromosomes at metaphase, and the right image is an interphase nucleus.

    QC Testing of FG0015
  • Supplied Product:
  • DAPI Counterstain (1500 ng/mL ) 250 uL
  • Storage Instruction:
  • Store at 4°C in the dark.
  • Note:

  • Hybridization position of the probes on the chromosome.

  • Probe 1:
        Size:
        Fluorophore:
        Location:
  • DYRK1A
    Approximately 570kb
    Texas Red
    21q22.13
  • Probe 2:
        Size:
        Fluorophore:
        Location:
  • CEN21q
    Approximately 520kb
    FITC
    21q11.2
  • Probe Gap:
  • The gap between two probes is approximately 14,000 kb.
  • Origin:
  • Human
  • Source:
  • Genomic DNA
  • Notice:
  • We strongly recommend the customer to use FFPE FISH PreTreatment Kit 1 (Catalog #: KA2375 or KA2691) for the pretreatment of Formalin-Fixed Paraffin-Embedded (FFPE) tissue sections.
  • Regulation Status:
  • For research use only (RUO)
  • Applications
  • Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
  • Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections) enlargeenlarge this image
  • Human hepatocellular carcinoma (FFPE) stained with DYRK1A/CEN21q FISH Probe. Human hepatocellular carcinoma showed no DYRK1A gene amplification.
  • PDF DownloadProtocol Download
  • Application Image
  • Fluorescent In Situ Hybridization (Cell)
  • Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
  • Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
  • enlarge
  • Gene Information
  • Entrez GeneID:
  • 1859
  • Gene Name:
  • DYRK1A
  • Gene Alias:
  • DYRK,DYRK1,HP86,MNB,MNBH
  • Gene Description:
  • dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
  • Gene Summary:
  • This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms. [provided by RefSeq
  • Other Designations:
  • MNB/DYRK protein kinase,OTTHUMP00000109090,dual specificity YAK1-related kinase,minibrain homolog,mnb protein kinase homolog hp86,protein kinase minibrain homolog,serine/threonine kinase MNB,serine/threonine-specific protein kinase
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