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Last updated: 2017/6/18

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p16/CEN9q FISH Probe

  • Catalog # : FG0002
  • Visit Frequency :
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  • Specification
  • Product Description:
  • Labeled FISH probes for identification of gene amplification using Fluoresecent In Situ Hybridization Technique. (Technology)
  • Quality Control Testing:
  • Representative images of normal human cell (lymphocyte) stain with the dual color FISH probe. The left image is chromosomes at metaphase, and the right image is an interphase nucleus.

    QC Testing of FG0002
  • Supplied Product:
  • DAPI Counterstain (1500 ng/mL ) 250 uL
  • Storage Instruction:
  • Store at 4°C in the dark.
  • Note:

  • Hybridization position of the probes on the chromosome.

  • Probe 1:
        Size:
        Fluorophore:
        Location:
  • p16
    Approximately 110kb
    Texas Red
    9p21
  • Probe 2:
        Size:
        Fluorophore:
        Location:
  • CEN9q
    Approximately 470kb
    FITC
    9q21
  • Probe Gap:
  • The gap between two probes is approximately 49,380 kb.
  • Origin:
  • Human
  • Source:
  • Genomic DNA
  • Notice:
  • We strongly recommend the customer to use FFPE FISH PreTreatment Kit 1 (Catalog #: KA2375 or KA2691) for the pretreatment of Formalin-Fixed Paraffin-Embedded (FFPE) tissue sections.
  • Regulation Status:
  • For research use only (RUO)
  • Applications
  • Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
  • Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections) enlargeenlarge this image
  • Human breast cancer (FFPE) stained with p16/CEN9q FISH Probe. Human breast cancer showed no p16 gene amplification
  • PDF DownloadProtocol Download
  • Application Image
  • Fluorescent In Situ Hybridization (Cell)
  • Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
  • Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
  • enlarge
  • Gene Information
  • Entrez GeneID:
  • 1029
  • Gene Name:
  • CDKN2A
  • Gene Alias:
  • ARF,CDK4I,CDKN2,CMM2,INK4,INK4a,MLM,MTS1,TP16,p14,p14ARF,p16,p16INK4,p16INK4a,p19
  • Gene Description:
  • cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)
  • Gene Summary:
  • This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, MDM1, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene. [provided by RefSeq
  • Other Designations:
  • CDK4 inhibitor p16-INK4,OTTHUMP00000021147,OTTHUMP00000021148,cell cycle negative regulator beta,cyclin-dependent kinase inhibitor 2A,cyclin-dependent kinase inhibitor p16,multiple tumor suppressor 1
  • Related Disease
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