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TUPLE1/ARSA FISH Probe

  • Catalog # : FA0654
  • Visit Frequency :
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  • Specification
  • Product Description:
  • Made to order FISH probes for identification of gene amplification using Fluorescent In Situ Hybridization Technique. (Technology)
  • Supplied Product:
  • DAPI Counterstain (150 ng/mL) 250 uL
  • Storage Instruction:
  • Store at 4°C in the dark.
  • Origin:
  • Human
  • Source:
  • Genomic DNA
  • Notice:
  • We strongly recommend the customer to use FFPE FISH PreTreatment Kit 1 (Catalog #: KA2375 or KA2691) for the pretreatment of Formalin-Fixed Paraffin-Embedded (FFPE) tissue sections.
  • Regulation Status:
  • For research use only (RUO)
  • Applications
  • Application Image
  • Fluorescent In Situ Hybridization (Cell)
  • Gene Information
  • Entrez GeneID:
  • 7290
  • Gene Name:
  • HIRA
  • Gene Alias:
  • DGCR1,TUP1,TUPLE1
  • Gene Description:
  • HIR histone cell cycle regulation defective homolog A (S. cerevisiae)
  • Gene Summary:
  • This gene encodes a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of this gene in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochomatin. This gene plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likely mediate the irreversible cell cycle changes that occur in senescent cells. It is considered the primary candidate gene in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryonic development. [provided by RefSeq
  • Other Designations:
  • DiGeorge critical region gene 1,HIR histone cell cycle regulation defective homolog A
  • Gene Information
  • Entrez GeneID:
  • 410
  • Gene Name:
  • ARSA
  • Gene Alias:
  • MLD
  • Gene Description:
  • arylsulfatase A
  • Gene Summary:
  • The protein encoded by this gene hydrolyzes cerebroside sulfate to cerebroside and sulfate. Defects in this gene lead to metachromatic leucodystrophy (MLD), a progressive demyelination disease which results in a variety of neurological symptoms and ultimately death. Multiple alternatively spliced transcript variants, one of which encodes a distinct protein, have been described for this gene. [provided by RefSeq
  • Other Designations:
  • OTTHUMP00000196546,OTTHUMP00000196548
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