CACYBP & SIAH1 Protein Protein Interaction Antibody Pair
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More Files
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Representative image of Proximity Ligation Assay of protein-protein interactions between CACYBP and SIAH1. HeLa cells were stained with anti-CACYBP rabbit purified polyclonal antibody 1:1200 and anti-SIAH1 mouse monoclonal antibody 1:50. Each red dot represents the detection of protein-protein interaction complex. The images were analyzed using an optimized freeware (BlobFinder) download from The Centre for Image Analysis at Uppsala University.
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Specification
Product Description
This protein protein interaction antibody pair set comes with two antibodies to detect the protein-protein interaction, one against the CACYBP protein, and the other against the SIAH1 protein for use in in situ Proximity Ligation Assay. See Publication Reference below.
Reactivity
Human
Quality Control Testing
Protein protein interaction immunofluorescence result.
Representative image of Proximity Ligation Assay of protein-protein interactions between CACYBP and SIAH1. HeLa cells were stained with anti-CACYBP rabbit purified polyclonal antibody 1:1200 and anti-SIAH1 mouse monoclonal antibody 1:50. Each red dot represents the detection of protein-protein interaction complex. The images were analyzed using an optimized freeware (BlobFinder) download from The Centre for Image Analysis at Uppsala University.
Supplied Product
Antibody pair set content:
1. CACYBP rabbit purified polyclonal antibody (100 ug)
2. SIAH1 mouse monoclonal antibody (40 ug)
*Reagents are sufficient for at least 30-50 assays using recommended protocols.Storage Instruction
Store reagents of the antibody pair set at -20°C or lower. Please aliquot to avoid repeated freeze thaw cycle. Reagents should be returned to -20°C storage immediately after use.
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Applications
In situ Proximity Ligation Assay (Cell)
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Gene Info — SIAH1
Entrez GeneID
6477Gene Name
SIAH1
Gene Alias
FLJ08065, HUMSIAH, Siah-1, Siah-1a, hSIAH1
Gene Description
seven in absentia homolog 1 (Drosophila)
Omim ID
602212Gene Ontology
HyperlinkGene Summary
This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in the development of certain forms of Parkinson's disease, the regulation of the cellular response to hypoxia and induction of apoptosis. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq
Other Designations
seven in absentia homolog 1|sonic hedgehog homolog
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Gene Info — CACYBP
Entrez GeneID
27101Gene Name
CACYBP
Gene Alias
GIG5, MGC87971, PNAS-107, RP1-102G20.6, S100A6BP, SIP
Gene Description
calcyclin binding protein
Omim ID
606186Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a calcyclin binding protein. It may be involved in calcium-dependent ubiquitination and subsequent proteosomal degradation of target proteins. It probably serves as a molecular bridge in ubiquitin E3 complexes and participates in the ubiquitin-mediated degradation of beta-catenin. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000032884|OTTHUMP00000032885|Siah-interacting protein (SIP)|growth-inhibiting gene 5 protein
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Interactome
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Pathway
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Disease
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