Products

In situ Proximity Ligation Assay (Cell)

Entrez GeneID

Gene Name

MAP3K3

Gene Alias

MAPKKK3, MEKK3

Gene Description

mitogen-activated protein kinase kinase kinase 3

Omim ID

Gene Ontology

Gene Summary

This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq

Other Designations

MAP/ERK kinase kinase 3|MAPK/ERK kinase kinase 3

Entrez GeneID

Gene Name

MAP2K5

Gene Alias

HsT17454, MAPKK5, MEK5, PRKMK5

Gene Description

mitogen-activated protein kinase kinase 5

Omim ID

Gene Ontology

Gene Summary

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been described. [provided by RefSeq

Other Designations

MAP kinase kinase MEK5b|MAPK/ERK kinase 5|dual specificity mitogen-activated protein kinase kinase 5