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MAP3K7 & MAP2K7 Protein Protein Interaction Antibody Pair

  • Catalog # : DI0489
  • Visit Frequency :
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  • Specification
  • Reactivity:
  • Human
  • Quality Control Testing:
  • Protein protein interaction immunofluorescence result.

    QC Testing of DI0489
    Representative image of Proximity Ligation Assay of protein-protein interactions between MAP3K7 and MAP2K7. HeLa cells were stained with anti-MAP3K7 rabbit purified polyclonal antibody 1:1200 and anti-MAP2K7 mouse monoclonal antibody 1:50. Each red dot represents the detection of protein-protein interaction complex. The images were analyzed using an optimized freeware (BlobFinder) download from The Centre for Image Analysis at Uppsala University.
  • Supplied Product:
  • Antibody pair set content:
    1. MAP3K7 rabbit purified polyclonal antibody (20 ug)
    2. MAP2K7 mouse monoclonal antibody (40 ug)
    *Reagents are sufficient for at least 30-50 assays using recommended protocols.
  • Storage Instruction:
  • Store reagents of the antibody pair set at -20°C or lower. Please aliquot to avoid repeated freeze thaw cycle. Reagents should be returned to -20°C storage immediately after use.
  • Publication Reference
  • Applications
  • In situ Proximity Ligation Assay (Cell)
  • Application Image
  • In situ Proximity Ligation Assay (Cell)
  • Gene Information
  • Entrez GeneID:
  • 6885
  • Gene Name:
  • MAP3K7
  • Gene Alias:
  • TAK1,TGF1a
  • Gene Description:
  • mitogen-activated protein kinase kinase kinase 7
  • Gene Summary:
  • The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq
  • Other Designations:
  • OTTHUMP00000016870,OTTHUMP00000016871,OTTHUMP00000016872,OTTHUMP00000016873,TGF-beta activated kinase 1,transforming growth factor-beta-activated kinase 1
  • Gene Information
  • Entrez GeneID:
  • 5609
  • Gene Name:
  • MAP2K7
  • Gene Alias:
  • Jnkk2,MAPKK7,MKK7,PRKMK7
  • Gene Description:
  • mitogen-activated protein kinase kinase 7
  • Gene Summary:
  • The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found, but only one transcript variant has been supported and defined. [provided by RefSeq
  • Other Designations:
  • JNK kinase 2,JNK-activating kinase 2,MAP kinase kinase 7,OTTHUMP00000174397,c-Jun N-terminal kinase kinase 2,dual specificity mitogen-activated protein kinase kinase 7
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