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ETS1 & NFKB1 Protein Protein Interaction Antibody Pair 

  • Catalog # : DI0482
  • Visit Frequency :
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  • Specification
  • Reactivity:
  • Human
  • Quality Control Testing:
  • Protein protein interaction immunofluorescence result.

    QC Testing of DI0482
    Representative image of Proximity Ligation Assay of protein-protein interactions between ETS1 and NFKB1. HeLa cells were stained with anti-ETS1 rabbit purified polyclonal antibody 1:1200 and anti-NFKB1 mouse monoclonal antibody 1:50. Each red dot represents the detection of protein-protein interaction complex. The images were analyzed using an optimized freeware (BlobFinder) download from The Centre for Image Analysis at Uppsala University.
  • Supplied Product:
  • Antibody pair set content:
    1. ETS1 rabbit purified polyclonal antibody (100 ug)
    2. NFKB1 mouse monoclonal antibody (40 ug)
    *Reagents are sufficient for at least 30-50 assays using recommended protocols.
  • Storage Instruction:
  • Store reagents of the antibody pair set at -20°C or lower. Please aliquot to avoid repeated freeze thaw cycle. Reagents should be returned to -20°C storage immediately after use.
  • Publication Reference
  • Applications
  • In situ Proximity Ligation Assay (Cell)
  • Application Image
  • In situ Proximity Ligation Assay (Cell)
  • Gene Information
  • Entrez GeneID:
  • 2113
  • Gene Name:
  • ETS1
  • Gene Alias:
  • ETS-1,EWSR2,FLJ10768
  • Gene Description:
  • v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)
  • Gene Summary:
  • ETS transcriptions factors, such as ETS1, regulate numerous genes and are involved in stem cell development, cell senescence and death, and tumorigenesis. The conserved ETS domain within these proteins is a winged helix-turn-helix DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T of target genes (Dwyer et al., 2007 [PubMed 17986575]).[supplied by OMIM
  • Other Designations:
  • Avian erythroblastosis virus E26 (v-ets) oncogene homolog-1,ets protein,v-ets avian erythroblastosis virus E2 oncogene homolog 1,v-ets avian erythroblastosis virus E26 oncogene homolog 1,v-ets erythroblastosis virus E26 oncogene homolog 1
  • Gene Information
  • Entrez GeneID:
  • 4790
  • Gene Name:
  • NFKB1
  • Gene Alias:
  • DKFZp686C01211,EBP-1,KBF1,MGC54151,NF-kappa-B,NFKB-p105,NFKB-p50,p105,p50
  • Gene Description:
  • nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
  • Gene Summary:
  • This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
  • Other Designations:
  • DNA binding factor KBF1,NF-kappabeta,nuclear factor NF-kappa-B p50 subunit,nuclear factor kappa-B DNA binding subunit,nuclear factor kappa-B, subunit 1
  • Interactome
  • Interactome
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