RXRA & ZBTB16 Protein Protein Interaction Antibody Pair
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Specification
Product Description
This protein protein interaction antibody pair set comes with two antibodies to detect the protein-protein interaction, one against the RXRA protein, and the other against the ZBTB16 protein for use in in situ Proximity Ligation Assay. See Publication Reference below.
Reactivity
Human
Quality Control Testing
Protein protein interaction immunofluorescence result.
Representative image of Proximity Ligation Assay of protein-protein interactions between RXRA and ZBTB16. HeLa cells were stained with anti-RXRA rabbit purified polyclonal antibody 1:1200 and anti-ZBTB16 mouse monoclonal antibody 1:50. Each red dot represents the detection of protein-protein interaction complex. The images were analyzed using an optimized freeware (BlobFinder) download from The Centre for Image Analysis at Uppsala University.
Supplied Product
Antibody pair set content:
1. RXRA rabbit purified polyclonal antibody (100 ug)
2. ZBTB16 mouse monoclonal antibody (40 ug)
*Reagents are sufficient for at least 30-50 assays using recommended protocols.Storage Instruction
Store reagents of the antibody pair set at -20°C or lower. Please aliquot to avoid repeated freeze thaw cycle. Reagents should be returned to -20°C storage immediately after use.
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Applications
In situ Proximity Ligation Assay (Cell)
Representative image of Proximity Ligation Assay of protein-protein interactions between RXRA and ZBTB16. PC-3 cells were stained with anti-RXRA rabbit purified polyclonal antibody 1:100 and anti-ZBTB16 mouse monoclonal antibody 1:50. Each red dot represents the detection of protein-protein interaction complex, and nuclei were counterstained with DAPI (blue).In situ Proximity Ligation Assay (Cell)
Representative image of Proximity Ligation Assay of protein-protein interactions between RXRA and ZBTB16. A-549 cells were stained with anti-RXRA rabbit purified polyclonal antibody 1:100 and anti-ZBTB16 mouse monoclonal antibody 1:50. Each red dot represents the detection of protein-protein interaction complex, and nuclei were counterstained with DAPI (blue). -
Gene Info — RXRA
Entrez GeneID
6256Gene Name
RXRA
Gene Alias
FLJ00280, FLJ00318, FLJ16020, FLJ16733, MGC102720, NR2B1
Gene Description
retinoid X receptor, alpha
Omim ID
180245Gene Ontology
HyperlinkGene Summary
Retinoid X receptors (RXRs) and retinoic acid receptors (RARs), are nuclear receptors that mediate the biological effects of retinoids by their involvement in retinoic acid-mediated gene activation. These receptors exert their action by binding, as homodimers or heterodimers, to specific sequences in the promoters of target genes and regulating their transcription. The protein encoded by this gene is a member of the steroid and thyroid hormone receptor superfamily of transcriptional regulators. [provided by RefSeq
Other Designations
OTTHUMP00000022510
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Gene Info — ZBTB16
Entrez GeneID
7704Gene Name
ZBTB16
Gene Alias
PLZF, ZNF145
Gene Description
zinc finger and BTB domain containing 16
Omim ID
176797Gene Ontology
HyperlinkGene Summary
This gene is a member of the Krueppel C2H2-type zinc-finger protein family and encodes a zinc finger transcription factor that contains nine Kruppel-type zinc finger domains at the carboxyl terminus. This protein is located in the nucleus, is involved in cell cycle progression, and interacts with a histone deacetylase. Specific instances of aberrant gene rearrangement at this locus have been associated with acute promyelocytic leukemia (APL). Alternate transcriptional splice variants have been characterized. [provided by RefSeq
Other Designations
Kruppel-like zinc finger protein|promyelocytic leukemia zinc finger protein|zinc finger protein 145 (Kruppel-like, expressed in promyelocytic leukemia)
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Interactome
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Disease
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