TRAF5 & TRAF3 Protein Protein Interaction Antibody Pair
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Representative image of Proximity Ligation Assay of protein-protein interactions between TRAF5 and TRAF3. HeLa cells were stained with anti-TRAF5 rabbit purified polyclonal antibody 1:1200 and anti-TRAF3 mouse monoclonal antibody 1:50. Each red dot represents the detection of protein-protein interaction complex. The images were analyzed using an optimized freeware (BlobFinder) download from The Centre for Image Analysis at Uppsala University.
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Specification
Product Description
This protein protein interaction antibody pair set comes with two antibodies to detect the protein-protein interaction, one against the TRAF5 protein, and the other against the TRAF3 protein for use in in situ Proximity Ligation Assay. See Publication Reference below.
Reactivity
Human
Quality Control Testing
Protein protein interaction immunofluorescence result.
Representative image of Proximity Ligation Assay of protein-protein interactions between TRAF5 and TRAF3. HeLa cells were stained with anti-TRAF5 rabbit purified polyclonal antibody 1:1200 and anti-TRAF3 mouse monoclonal antibody 1:50. Each red dot represents the detection of protein-protein interaction complex. The images were analyzed using an optimized freeware (BlobFinder) download from The Centre for Image Analysis at Uppsala University.
Supplied Product
Antibody pair set content:
1. TRAF5 rabbit purified polyclonal antibody (100 ug)
2. TRAF3 mouse monoclonal antibody (40 ug)
*Reagents are sufficient for at least 30-50 assays using recommended protocols.Storage Instruction
Store reagents of the antibody pair set at -20°C or lower. Please aliquot to avoid repeated freeze thaw cycle. Reagents should be returned to -20°C storage immediately after use.
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Applications
In situ Proximity Ligation Assay (Cell)
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Gene Info — TRAF3
Entrez GeneID
7187Gene Name
TRAF3
Gene Alias
CAP-1, CD40bp, CRAF1, LAP1
Gene Description
TNF receptor-associated factor 3
Omim ID
601896Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from, members of the TNF receptor (TNFR) superfamily. This protein participates in the signal transduction of CD40, a TNFR family member important for the activation of the immune response. This protein is found to be a critical component of the lymphotoxin-beta receptor (LTbetaR) signaling complex, which induces NF-kappaB activation and cell death initiated by LTbeta ligation. Epstein-Barr virus encoded latent infection membrane protein-1 (LMP1) can interact with this and several other members of the TRAF family, which may be essential for the oncogenic effects of LMP1. Three alternatively spliced transcript variants encoding two distinct isoforms have been reported. [provided by RefSeq
Other Designations
CD40 associated protein 1|CD40 binding protein|CD40 receptor associated factor 1|LMP1 associated protein
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Gene Info — TRAF5
Entrez GeneID
7188Gene Name
TRAF5
Gene Alias
MGC:39780, RNF84
Gene Description
TNF receptor-associated factor 5
Omim ID
602356Gene Ontology
HyperlinkGene Summary
The scaffold protein encoded by this gene is a member of the tumor necrosis factor receptor-associated factor (TRAF) protein family and contains a meprin and TRAF homology (MATH) domain, a RING-type zinc finger, and two TRAF-type zinc fingers. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. This protein is one of the components of a multiple protein complex which binds to tumor necrosis factor (TNF) receptor cytoplasmic domains and mediates TNF-induced activation. Alternate transcriptional splice variants have been characterized. [provided by RefSeq
Other Designations
OTTHUMP00000035055|OTTHUMP00000035056|RING finger protein 84
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Interactome
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Pathway
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Disease
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