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XIAP & ACVR1B Protein Protein Interaction Antibody Pair

  • Catalog # : DI0405
  • Visit Frequency :
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  • Specification
  • Reactivity:
  • Human
  • Quality Control Testing:
  • Protein protein interaction immunofluorescence result.

    QC Testing of DI0405
    Representative image of Proximity Ligation Assay of protein-protein interactions between XIAP and ACVR1B. HeLa cells were stained with anti-XIAP rabbit purified polyclonal antibody 1:1200 and anti-ACVR1B mouse monoclonal antibody 1:50. Each red dot represents the detection of protein-protein interaction complex. The images were analyzed using an optimized freeware (BlobFinder) download from The Centre for Image Analysis at Uppsala University.
  • Supplied Product:
  • Antibody pair set content:
    1. XIAP rabbit purified polyclonal antibody (20 ug)
    2. ACVR1B mouse monoclonal antibody (40 ug)
    *Reagents are sufficient for at least 30-50 assays using recommended protocols.
  • Storage Instruction:
  • Store reagents of the antibody pair set at -20°C or lower. Please aliquot to avoid repeated freeze thaw cycle. Reagents should be returned to -20°C storage immediately after use.
  • Publication Reference
  • Applications
  • In situ Proximity Ligation Assay (Cell)
  • Application Image
  • In situ Proximity Ligation Assay (Cell)
  • Gene Information
  • Entrez GeneID:
  • 331
  • Gene Name:
  • XIAP
  • Gene Alias:
  • API3,BIRC4,ILP1,MIHA,XLP2
  • Gene Description:
  • X-linked inhibitor of apoptosis
  • Gene Summary:
  • The protein encoded by this gene is a member of a family of proteins which inhibit apoptosis through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2. This protein inhibits apoptosis induced by menadione, a potent inducer of free radicals, and ICE. It also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. [provided by RefSeq
  • Other Designations:
  • OTTHUMP00000023975,OTTHUMP00000196392,apoptosis inhibitor 3,baculoviral IAP repeat-containing 4,baculoviral IAP repeat-containing protein 4
  • Gene Information
  • Entrez GeneID:
  • 91
  • Gene Name:
  • ACVR1B
  • Gene Alias:
  • ACTRIB,ACVRLK4,ALK4,SKR2
  • Gene Description:
  • activin A receptor, type IB
  • Gene Summary:
  • Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with a cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type IB receptor, composed of 11 exons. Alternative splicing and alternative polyadenylation result in 3 fully described transcript variants. The mRNA expression of variants 1, 2, and 3 is confirmed, and a potential fourth variant contains an alternative exon 8 and lacks exons 9 through 11, but its mRNA expression has not been confirmed. [provided by RefSeq
  • Other Designations:
  • activin A receptor, type II-like kinase 4,activin A type IB receptor,activin receptor-like kinase 4,serine(threonine) protein kinase receptor R2
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