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ATF4 & FOS Protein Protein Interaction Antibody Pair

  • Catalog # : DI0361
  • Visit Frequency :
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  • Specification
  • Reactivity:
  • Human
  • Quality Control Testing:
  • Protein protein interaction immunofluorescence result.

    QC Testing of DI0361
    Representative image of Proximity Ligation Assay of protein-protein interactions between ATF4 and FOS. HeLa cells were stained with anti-ATF4 rabbit purified polyclonal antibody 1:1200 and anti-FOS mouse monoclonal antibody 1:50. Each red dot represents the detection of protein-protein interaction complex. The images were analyzed using an optimized freeware (BlobFinder) download from The Centre for Image Analysis at Uppsala University.
  • Supplied Product:
  • Antibody pair set content:
    1. ATF4 rabbit purified polyclonal antibody (20 ug)
    2. FOS mouse monoclonal antibody (40 ug)
    *Reagents are sufficient for at least 30-50 assays using recommended protocols.
  • Storage Instruction:
  • Store reagents of the antibody pair set at -20°C or lower. Please aliquot to avoid repeated freeze thaw cycle. Reagents should be returned to -20°C storage immediately after use.
  • Publication Reference
  • Applications
  • In situ Proximity Ligation Assay (Cell)
  • Application Image
  • In situ Proximity Ligation Assay (Cell)
  • Gene Information
  • Entrez GeneID:
  • 468
  • Gene Name:
  • ATF4
  • Gene Alias:
  • CREB-2,CREB2,TAXREB67,TXREB
  • Gene Description:
  • activating transcription factor 4 (tax-responsive enhancer element B67)
  • Gene Summary:
  • This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromsome at q28 in a region containing a large inverted duplication. [provided by RefSeq
  • Other Designations:
  • activating transcription factor 4,cAMP response element-binding protein 2
  • Gene Information
  • Entrez GeneID:
  • 2353
  • Gene Name:
  • FOS
  • Gene Alias:
  • AP-1,C-FOS
  • Gene Description:
  • v-fos FBJ murine osteosarcoma viral oncogene homolog
  • Gene Summary:
  • The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of the FOS gene has also been associated with apoptotic cell death. [provided by RefSeq
  • Other Designations:
  • FBJ murine osteosarcoma viral (v-fos) oncogene homolog (oncogene FOS),activator protein 1,cellular oncogene c-fos
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