APC & CSNK1E Protein Protein Interaction Antibody Pair
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Specification
Product Description
This protein protein interaction antibody pair set comes with two antibodies to detect the protein-protein interaction, one against the APC protein, and the other against the CSNK1E protein for use in in situ Proximity Ligation Assay. See Publication Reference below.
Reactivity
Human
Quality Control Testing
Protein protein interaction immunofluorescence result.
Representative image of Proximity Ligation Assay of protein-protein interactions between APC and CSNK1E. HeLa cells were stained with anti-APC rabbit purified polyclonal antibody 1:1200 and anti-CSNK1E mouse monoclonal antibody 1:50. Each red dot represents the detection of protein-protein interaction complex. The images were analyzed using an optimized freeware (BlobFinder) download from The Centre for Image Analysis at Uppsala University.
Supplied Product
Antibody pair set content:
1. APC rabbit purified polyclonal antibody (100 ug)
2. CSNK1E mouse monoclonal antibody (40 ug)
*Reagents are sufficient for at least 30-50 assays using recommended protocols.Storage Instruction
Store reagents of the antibody pair set at -20°C or lower. Please aliquot to avoid repeated freeze thaw cycle. Reagents should be returned to -20°C storage immediately after use.
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Applications
In situ Proximity Ligation Assay (Cell)
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Gene Info — APC
Entrez GeneID
324Gene Name
APC
Gene Alias
BTPS2, DP2, DP2.5, DP3, GS
Gene Description
adenomatous polyposis coli
Gene Ontology
HyperlinkGene Summary
This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. [provided by RefSeq
Other Designations
adenomatosis polyposis coli tumor suppressor
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Gene Info — CSNK1E
Entrez GeneID
1454Gene Name
CSNK1E
Gene Alias
HCKIE, MGC10398
Gene Description
casein kinase 1, epsilon
Omim ID
600863Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a serine/threonine protein kinase and a member of the casein kinase I protein family, whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein is found in the cytoplasm as a monomer and can phosphorylate a variety of proteins, including itself. This protein has been shown to phosphorylate period, a circadian rhythm protein. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq
Other Designations
CKI-epsilon|OTTHUMP00000063258|OTTHUMP00000063263|casein kinase 1 epsilon|casein kinase I epsilon
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Interactome
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Pathway
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Disease
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